The investigation of the adaptogenic properties of Rhodo dendron adamsii Rehder. on experimental models in vivo

Authors

  • Aksana I. Hubich Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Kristina V. Puchkova Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Natalya A. Zalesskaya Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Natalya V. Kryuchkova Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

Keywords:

adaptogen, carbohydrate metabolism, energy exchange, exercises, experimental hyperphagy, alloxan- induced diabetes mellitus

Abstract

This work is devoted to the study of the influence of Rhododendron adamsii Rehder. on the energy and carbohydrate metabolism of laboratory mice under conditions of physical activity, as well as to the analysis of the possibility of correction of biochemical markers of carbohydrate metabolism in laboratory rats with experimental diabetes mellitus and experimental hyperphagia. It has been established that in the conditions of physical activity the Rhododendron decoction shows adaptogenic properties, which is manifested by higher values of the content of creatine phosphate and the total pool of macroergs in skeletal muscles, as well as the glucose concentration in the blood of the animals received this preparation, in comparison with the corresponding control, while Rhododendron adamsii has a minimal effect on the energy and carbohydrate metabolism of intact animals, and its double overdose is not accompanied by the appearance of seizures, hyperactivity and increased aggression, in contrast to the commercial energy drink «Hell» (the reference drug). It is shown that the use of Rhododendron decoction by the rats with experimental hyperphagia and experimental diabetes mellitus contributes to the partial normalization of carbohydrate metabolism markers (a-amylase activity, glucose concentration, pyruvate content). The effect of the prepatation tested was more pronounced under alloxan diabetes than the effect of the anti-diabetic «Sadifit» collection. The results obtained may be due to the presence of flavonoids, ascorbic acid and unsaturated fatty acids showing an antioxidant effect, as well as glycosides, terpenes and diterpenes, which promote the permeability of the cell membrane for glucose.

Author Biographies

  • Aksana I. Hubich, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

    PhD (biology), docent; associate professor at the department of biochemistry, faculty of biology

  • Kristina V. Puchkova, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

    student at the faculty of biology

  • Natalya A. Zalesskaya, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

    student at the faculty of biology

  • Natalya V. Kryuchkova, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

    student at the faculty of biology

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Published

2018-05-03

Issue

No. 1 (2018): Journal of the Belarusian State University. Biology

Section

Biochemistry, Biotechnology and Microbiology

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How to Cite

Hubich, A. I., Puchkova, K. V., Zalesskaya, N. A., & Kryuchkova, N. V. (2018). The investigation of the adaptogenic properties of Rhodo dendron adamsii Rehder. on experimental models in vivo. Experimental Biology and Biotechnology, 1, 60-68. https://journals.bsu.by/index.php/biology/article/view/2487