Effect of diisononyl phthalate on the endocrine system of generation of white rats


We studied the state of the endocrine system of males of the offspring of white rats subjected to the action of the new plasticizer diisononyl phthalate during pregnancy. The effect of doses of 100 and 1000 mg/kg was characterized by a staggering increase in total thyroxine levels by 2.3 and 2.0 times, thyroid stimulating hormone by 2.3 and 2.1 times, a decrease  in testosterone concentration of 2.9 and 2.3 times, respectively. The established changes in the hormonal profile indicate the development of thyrotoxicosis and primary testicular insufficiency in male descendants involving the pathological process of the pituitary and (or) hypothalamus. In the experiment, the most inactive dose was 10 mg/kg of diisononyl phthalate, the effect of which on pregnant females had no effect on the hormonal status of offspring in the postnatal period of development.

Author Biography

Vitali A. Hrynchak, Scientific Practical Centre of Hygiene, 8 Akademičnaja Street, Minsk 220012, Belarus

junior researcher of the laboratory of preventive and ecological toxicology


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Keywords: diisononyl phthalate, DINP, phthalate, reproductive toxicity, hormones, testosterone
How to Cite
Hrynchak, V. A. (2019). Effect of diisononyl phthalate on the endocrine system of generation of white rats. Experimental Biology and Biotechnology, 3, 79-84. Retrieved from https://journals.bsu.by/index.php/biology/article/view/2538