Effect of diisononyl phthalate on the endocrine system of generation of white rats

Abstract

We studied the state of the endocrine system of males of the offspring of white rats subjected to the action of the new plasticizer diisononyl phthalate during pregnancy. The effect of doses of 100 and 1000 mg/kg was characterized by a staggering increase in total thyroxine levels by 2.3 and 2.0 times, thyroid stimulating hormone by 2.3 and 2.1 times, a decrease  in testosterone concentration of 2.9 and 2.3 times, respectively. The established changes in the hormonal profile indicate the development of thyrotoxicosis and primary testicular insufficiency in male descendants involving the pathological process of the pituitary and (or) hypothalamus. In the experiment, the most inactive dose was 10 mg/kg of diisononyl phthalate, the effect of which on pregnant females had no effect on the hormonal status of offspring in the postnatal period of development.

Author Biography

Vitali A. Hrynchak, Scientific Practical Centre of Hygiene, 8 Akademičnaja Street, Minsk 220012, Belarus

junior researcher of the laboratory of preventive and ecological toxicology

References

  1. Hrynchak VA, Sychik SI. [Actual problems of safe handling of diisononyl phthalate]. Trudy Belorusskogo gosudarstvennogo universiteta. Fiziologicheskie, biokhimicheskie i molekulyarnye osnovy funktsionirovaniya biosistem [Proceedings of the Belarusian State University. Physiological, biochemical and molecular basis of functioning of biosystems]. 2016;11(2):36 – 46. Russian.
  2. [Requirements for medical devices and medical equipment: approved]. In: Edinye sanitarno-epidemiologicheskie i gigienicheskie trebovaniya k tovaram, podlezhashchim sanitarno-epidemiologicheskomu nadzoru (kontrolyu): utverzhdeny resheniem Komissii Tamozhennogo soyuza ot 28 maya 2010 g. № 299 [Uniform sanitary and epidemiological and hygienic requirements for goods subject to sanitary and epidemiological surveillance (control): approved by the Decision of the Commission of the Customs Union of 28 May 2010 No. 299]. Chapter II, section 18. p. 1141–1259. Russian.
  3. Assessing Human Health Risks of Chemicals: Derivation of Guidance Values for Health-based Exposure limits. World Health Organization. IPCS Environmental Health Criteria 170 [Internet]. [Cited 2018 January 4];1994:75. Available from: http://www.who.int/iris/handle/10665/40675.
  4. Guidelines for Reproductive Toxicity Risk Assessment. United States Environmental Protection Agency; September 1996. p. 163.
  5. Hrynchak VA, Sychik SI, Vlasenko EK, Ilyukova II, Ryabtseva SN. Study of embryotoxic and teratogenic action of diisononyl phthalate. Toxicological Review. 2017;5:22–27. Russian.
  6. Beletskaya EN, Onul NM. Zinc influence on reproductive funсtion of experimental animals. Trace elements in medicine. 2014;15(2):22–28. Russian.
  7. Guide for the care and use of laboratory animals. Washington: National academies press; 1996. 128 p.
  8. Kamyshnikov VS. Laboratornaya diagnostika vnutrennikh i khirurgicheskikh boleznei [Laboratory diagnostics of internal and surgical diseases]. Minsk: Adukacyja i vyhavanne; 2012. Russian.
Published
2019-01-18
Keywords: diisononyl phthalate, DINP, phthalate, reproductive toxicity, hormones, testosterone
How to Cite
Hrynchak, V. A. (2019). Effect of diisononyl phthalate on the endocrine system of generation of white rats. Experimental Biology and Biotechnology, 3, 79-84. Retrieved from https://journals.bsu.by/index.php/biology/article/view/2538