Assessment of antinociceptive actions of fatty acid amides in pharmacological blockade of PPARα receptors in experimental peripheral neuropathy

  • Anastasya S. Doronkina Institute of Physiology, National Academy of Sciences of Belarus, 28 Akademichnaja Street, Minsk 220072, Belarus
  • Irina P. Zhavoronok Institute of Physiology, National Academy of Sciences of Belarus, 28 Akademichnaja Street, Minsk 220072, Belarus
  • Alexander L. Mikhal’chuk Institute of Bioоrganic Chemistry, National Academy of Sciences of Belarus, 5 Akademika Kuprevicha Street, 2 building, Minsk 220084, Belarus
  • Vasily G. Bogdan National Academy of Sciences of Belarus, 66 Niezaliezhnasci Avenue, Minsk 220072, Belarus

Abstract

The effect of fatty acid amides during the blockade of PPARα nuclear receptors on nociceptive sensitivity and gait parameters in rats with normal and experimental peripheral neuropathy was studied. It was found that in rats with ligation of the sciatic nerve, the introduction of fatty acid amides against the background of PPARα receptor blockade led to a significant decrease in the severity of the nociceptive response to mechanical and thermal stimuli. When registering gait patterns, an increase in the intensity and area of the limb imprint, as well as in limb transfer rate was noted.

Author Biographies

Anastasya S. Doronkina, Institute of Physiology, National Academy of Sciences of Belarus, 28 Akademichnaja Street, Minsk 220072, Belarus

junior researcher at the laboratory of biological modelling

Irina P. Zhavoronok, Institute of Physiology, National Academy of Sciences of Belarus, 28 Akademichnaja Street, Minsk 220072, Belarus

PhD (biology); head of the laboratory of biological modelling

Alexander L. Mikhal’chuk, Institute of Bioоrganic Chemistry, National Academy of Sciences of Belarus, 5 Akademika Kuprevicha Street, 2 building, Minsk 220084, Belarus

кандидат химических наук; ведущий научный сотрудник, исполняющий обязанности заведующего лабораторией химии липидов

Vasily G. Bogdan, National Academy of Sciences of Belarus, 66 Niezaliezhnasci Avenue, Minsk 220072, Belarus

doctor of science (medicine), full professor; academician-secretary at the Department of Medical Sciences

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Published
2023-06-22
Keywords: palmitoylethanolamide, stearoylethanolamide, palmitoylglycinamide, gait patterns, nociception, neuropathy, analgesic effect, fatty acid amides, nuclear receptors
How to Cite
Doronkina, A. S., Zhavoronok, I. P., Mikhal’chuk, A. L., & Bogdan, V. G. (2023). Assessment of antinociceptive actions of fatty acid amides in pharmacological blockade of PPARα receptors in experimental peripheral neuropathy. Experimental Biology and Biotechnology, 2, 30-43. Retrieved from https://journals.bsu.by/index.php/biology/article/view/5338
Issue
No 2 (2023): Experimental Biology and Biotechnology
Section
Cell Biology and Physiology

Copyright (c) 2023 Experimental Biology and Biotechnology

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