Analysis of changes of the rats’ peripheral blood with prolonged exposure to various dose multicomponent means

Authors

  • Anna V. Adamovich Scientific practical centre of hygiene, Akademichnaja Street, 8, 220012, Minsk, Belarus
  • Elena A. Rimzha Belarusian Medical Academy of Post-graduate Education, P. Broǔki Street, 3/3, 220013, Minsk, Belarus
  • Galina V. Sherstyuk Belarusian Medical Academy of Post-graduate Education, P. Broǔki Street, 3/3, 220013, Minsk, Belarus
  • Natallia V. Dudchyk Scientific practical centre of hygiene, Akademichnaja Street, 8, 220012, Minsk, Belarus

Keywords:

antinicotine composition, hematologic parameters

Abstract

The article presents results of studying potential toxicity of the original multicomponent composition for prevention and correction of tobacco use effects. At one of the toxicological studies stages, the effect of multiple intake of this composition on the state of peripheral blood of laboratory animals (rats) was evaluated. The results of 30- and 60day experiments revealed a few changes in individual hematological parameters, which depended on the admission duration and the dose of the drug. The character of the changes suggests that they are an adaptive response of the body to the long-term influence of a complex of xenobiotics with a multiple effects. In general, assessment of the animals’ hematologic status on the both experimental dates, the depth and temporality of the revealed changes indicate the absence of a pronounced toxic effect of the composition at its long-term use.

Author Biographies

  • Anna V. Adamovich, Scientific practical centre of hygiene, Akademichnaja Street, 8, 220012, Minsk, Belarus

    junior researcher

  • Elena A. Rimzha, Belarusian Medical Academy of Post-graduate Education, P. Broǔki Street, 3/3, 220013, Minsk, Belarus

    doctor of science (medicine); chief researcher

  • Galina V. Sherstyuk, Belarusian Medical Academy of Post-graduate Education, P. Broǔki Street, 3/3, 220013, Minsk, Belarus

    PhD (biology); leading researcher

  • Natallia V. Dudchyk, Scientific practical centre of hygiene, Akademichnaja Street, 8, 220012, Minsk, Belarus

    doctor of science (biology); head of the laboratory of microbiology

References

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Published

2017-12-16

Issue

No. 2 (2017): Journal of the Belarusian State University. Biology

Section

Physiology and Сell Biology

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How to Cite

Adamovich, A. V., Rimzha, E. A., Sherstyuk, G. V., & Dudchyk, N. V. (2017). Analysis of changes of the rats’ peripheral blood with prolonged exposure to various dose multicomponent means. Experimental Biology and Biotechnology, 2, 31-35. https://journals.bsu.by/index.php/biology/article/view/2442