The ability of the natural chemoprophylactic agent curcumin to function as an effective UV photosensitiser

Authors

  • Alla I. Potapovich Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Tatsiana G. Shutava Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Tatyana V. Kostyuk Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Vladimir A. Kostyuk Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

Keywords:

UV radiation, curcumin, photosensitiser, nanostructures, HaCaT, MDA-MB-231

Abstract

It is known that some plant polyphenols and alkaloids can act as effective photosensitisers of UV radiation. This phenomenon can enhance both therapeutic and side effects. Since there is no information regarding curcuminoids on their ability to function as UV photosensitisers, this work investigated the effect of UV radiation on the cytotoxic effect of curcumin, as well as its nanostructured forms, against keratinocytes of the HaCaT line and cancer cells MDA-MB-231. The results obtained indicate that curcumin is an effective photosensitiser capable of initiating photochemical reactions under the influence of UV radiation of the A and B range, which lead to the formation of chemically active intermediates, disruption of membrane integrity and cell death. When curcumin is incorporated into nanostructures based on polyallylamine hydrochloride /polystyrene sulfate and chitosan /dextran sulfate, its ability to function as a UV photosensitiser is retained.

Author Biographies

  • Alla I. Potapovich, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

    PhD (biology); leading researcher at the laboratory of physiology, department of human and animal physiology, faculty of biology

  • Tatsiana G. Shutava, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

    PhD (chemistry); leading researcher at the laboratory of biopolymer encapsulated structures, department of physical chemistry of thin-film materials

  • Tatyana V. Kostyuk, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

    junior researcher at the laboratory of physiology, department of human and animal physiology, faculty of biology

  • Vladimir A. Kostyuk, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

    doctor of science (chemistry), docent; head of the laboratory of physiology, department of human and animal physiology, faculty of biology

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Published

2021-11-05

Issue

No. 3 (2021): Journal of the Belarusian State University. Biology

Section

Physiology and Сell Biology

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How to Cite

Potapovich, A. I., Shutava, T. G., Kostyuk, T. V., & Kostyuk, V. A. (2021). The ability of the natural chemoprophylactic agent curcumin to function as an effective UV photosensitiser. Experimental Biology and Biotechnology, 3, 28-37. https://doi.org/10.33581/2521-1722-2021-3-28-37