Obtaining and assessing the biological activity of quercetin included in polydisperse nanoparticles of zein

Authors

  • Alla I. Potapovich Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Tatyana V. Kostyuk Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Tatsiana G. Shutava Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, 36 F. Skaryny Street, Minsk 220141, Belarus
  • Vladimir A. Kostyuk Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

Keywords:

HaCaT keratinocytes, zein, quercetin, nanostructures, oxidative stress, DNA damage

Abstract

The corn protein zein was used to obtain quercetin-containing nanoparticles. It has been shown that quercetin included in the zein matrix retains antiradical activity in the reaction with 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) radical cations. It was found that both native quercetin and structured quercetin in zein nanoparticles reduce damage to plasma membranes and nuclear DNA of cells caused by bactericidal UV irradiation. Thus, corn protein zein can be used to obtain quercetin-containing nanoparticles that retain the biological activity of native quercetin.

Author Biographies

  • Alla I. Potapovich, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

    PhD (biology), docent; leading researcher at the laboratory of physiology, department of human and animal physiology, faculty of biology

  • Tatyana V. Kostyuk, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

    researcher at the laboratory of physiolo­gy, de­partment of human and animal physiology, faculty of biology

  • Tatsiana G. Shutava, Institute of Chemistry of New Materials, National Academy of Sciences of Belarus, 36 F. Skaryny Street, Minsk 220141, Belarus

    PhD (chemistry), docent; leading resear­ cher at the laboratory of organic composite materials

  • Vladimir A. Kostyuk, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

    doctor of science (chemistry), full professor; head of the laboratory of physiology, department of human and animal physiology, faculty of biology

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Published

2024-11-19

Issue

No. 3 (2024): Experimental Biology and Biotechnology

Section

Physiology and Сell Biology

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How to Cite

Obtaining and assessing the biological activity of quercetin included in polydisperse nanoparticles of zein. (2024). Experimental Biology and Biotechnology, 3, 4-9. https://journals.bsu.by/index.php/biology/article/view/6428