Entropy dynamics interpretation in genetic studies with the multifactor dimensionality reduction method

Authors

  • Uladzimir A. Ivaniukovich International Sakharov Environmental Institute, Belarusian State University, 23/1 Dawgabrodskaja Street, Minsk 220070, Belarus
  • Sergei B. Melnov Belarusian State University of Physical Culture, 105 Peramozhcaw Avenue, Minsk 220020, Belarus
  • Ma Min Belarusian State University of Physical Culture, 105 Peramozhcaw Avenue, Minsk 220020, Belarus

Keywords:

genetics, simulation, multifactor dimensionality reduction, gene – gene interactions, genotype, phenotype, entropy, statistical analysis, classification

Abstract

The multifactor dimensionality reduction (MDR) method allows to select the predictor (gene, allele) combinations corresponding to a particular phenotype (outcome) with high precision. However, the entropy change graph and interaction dendrogram constructed in the MDR (version 3.0.2) software implementing this method do not characterize gene – gene interactions. Using examples of athlete classification based on their genotypes, it is shown that the software constructs a statistical entropy change graph when reducing dimensionality, which does not correspond to the strength and direction of real gene – gene interactions, but describes the efficiency of predictor convolution when combining two or more factors in order to achieve maximum accuracy in classifying outcomes.

Author Biographies

  • Uladzimir A. Ivaniukovich, International Sakharov Environmental Institute, Belarusian State University, 23/1 Dawgabrodskaja Street, Minsk 220070, Belarus

    PhD (physics and mathematics), docent; associate professor at the department of information technologies in ecology and medicine, faculty of environmental monitoring

  • Sergei B. Melnov, Belarusian State University of Physical Culture, 105 Peramozhcaw Avenue, Minsk 220020, Belarus

    doctor of science (biology), full professor; professor at the department of anatomy, faculty of health-improving physical education

  • Ma Min, Belarusian State University of Physical Culture, 105 Peramozhcaw Avenue, Minsk 220020, Belarus

    postgraduate student at the department of anatomy, faculty of health-improving physical education

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Published

2025-03-06

Issue

No. 1 (2025): Experimental Biology and Biotechnology

Section

Genetics and Molecular Biology

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How to Cite

Ivaniukovich, U. A. ., Melnov, S. B. ., & Min, M. . (2025). Entropy dynamics interpretation in genetic studies with the multifactor dimensionality reduction method. Experimental Biology and Biotechnology, 1, 40-46. https://journals.bsu.by/index.php/biology/article/view/6509