Role of reorganization of mitochondria structure in age-dependent changes of adrenal cortex function

Authors

  • Ekaterina P. Timokhina Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia https://orcid.org/0000-0003-0504-1488
  • Valentin V. Yaglov Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia
  • Sergey S. Obernikhin Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia
  • Natalia V. Yaglova Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia
  • Svetlana V. Nazimova Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia
  • Dibakhan A. Tsomartova Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

Keywords:

mitochondrion, adrenal gland, adrenal cortical cell, steroidogenesis, steroid hormones, postnatal development

Abstract

Steroidogenic activity of adrenal cortical cells is known to change significantly during postnatal development. Age-dependent changes of mitochondrial apparatus and its impact in secretory activity of the adrenal cortex are less studied. The aim was to uncover age-dependent mitochondrial dynamics in rat glomerulosa, fasciculata and reticularis cells, and to assess them together with changes in adrenal cortex morphology and function. Pubertal and postpubertal male Wistar rats were used in the research. Quantitative parameters of adrenal cortex morphology and fine structure of adrenocortical cells were examined by light and transmission electron microscopy. Production of adrenal hormones was evaluated by enzyme-linked immunosorbent assay. Discrete age-dependent changes of mitochondrial dynamics was revealed. These changes were found more sufficient for hormone production then alterations in morphology of adrenocortical zones. Association of changes in mitochondrial structure with intensity of hormone secretion demonstrate that morphological studies of adrenal cortex requires examination of fine structure for correct assessment of adrenal development.

Author Biographies

  • Ekaterina P. Timokhina, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    PhD (biology); researcher at the laboratory of endocrine system development

  • Valentin V. Yaglov, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    doctor of science (medicine), full professor; chief researcher at the laboratory of endocrine system development

  • Sergey S. Obernikhin, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    doctor of science (medicine); senior researcher at the laboratory of endocrine system development

  • Natalia V. Yaglova, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    doctor of science (medicine); head of the laboratory of endocrine system development

  • Svetlana V. Nazimova, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    PhD (medicine); senior researcher at the laboratory of endocrine system development

  • Dibakhan A. Tsomartova, Research Institute of Human Morphology, 3 Tsyurupy Street, Moscow 117418, Russia

    PhD (medicine); junior researcher at the laboratory of endocrine system development

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Published

2020-12-31

Issue

No. 3 (2020): Journal of the Belarusian State University. Biology

Section

Cell Biology and Physiology

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How to Cite

Timokhina, E. P., Yaglov, V. V., Obernikhin, S. S., Yaglova, N. V., Nazimova, S. V., & Tsomartova, D. A. . (2020). Role of reorganization of mitochondria structure in age-dependent changes of adrenal cortex function. Experimental Biology and Biotechnology, 3, 13-18. https://doi.org/10.33581/2521-1722-2020-3-13-18