Extraction of chloramphenicol with organic solvents

Authors

  • Anna G. Polonevich Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus
  • Sergey M. Leschev Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Alena I. Palianskikh Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus
  • Liudmila L. Belysheva Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus

Keywords:

chloramphenicol, liquid-liquid extraction, distribution constants, high-performance liquid chromatography, tandem mass spectrometry, foodstuffs

Abstract

The distribution constants of chloramphenicol in the aqueous phase – organic solvent extraction systems have been experimentally determined. The relationship between the obtained values of the constants and the nature of the extraction systems phases was analysed. It has been shown that for the extraction of chloramphenicol from food products of animal origin, it is appropriate to use dichloromethane combined with salting out with ammonium sulfate. The sample preparation technique for chloramphenicol trace amounts determination with high-performance liquid chromatography with tandem mass spectrometry based on salting-out liquid-liquid extraction with dichloromethane has been developed.

Author Biographies

  • Anna G. Polonevich, Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus

    leading chemist at the laboratory of food chemistry

  • Sergey M. Leschev, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

    doctor of science (chemistry), full professor; professor at the department of analytical chemistry, faculty of chemistry

  • Alena I. Palianskikh, Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus

    PhD (chemistry); leading researcher at the laboratory of food chemistry

  • Liudmila L. Belysheva, Scientific Practical Centre of Hygiene, 8 Akademichnaja Street, Minsk 220012, Belarus

    head of the laboratory of food chemistry

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Published

2023-09-20

Issue

No. 2 (2023): Journal of the Belarusian State University. Chemistry

Section

Original Articles

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How to Cite

[1]
Polonevich, A.G. et al. 2023. Extraction of chloramphenicol with organic solvents. Journal of the Belarusian State University. Chemistry. 2 (Sep. 2023), 35–41.