Bioactive Ni(II) complexes with catechol derivatives

Authors

  • Hleb I. Harbatsevich Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Natalia V. Loginova Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Kseniya A. Nabebina Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Sergei I. Stakhevich Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk
  • Irina N. Slabko Scientific Research Department of Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk
  • Nikolai P. Osipovich Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk
  • Galina A. Ksendzova Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk
  • Igor I. Azarko Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

Keywords:

Ni(II) complexes, catechol derivatives, cytochrome c reduction, antimicrobial activity

Abstract

The complexation process of Ni(II) ions with catechol derivatives in water-ethanol medium was investigated. It was found potentiometrically that complexes with the ratio M : L = 1 : 2 were formed in solution, their overall stability constants were equal to 7,9 ⋅ 1014 – 1,6 ⋅ 1015. The Ni(II) complexes synthesized were shown to be amorphous, neutral, and thermally stable up to 150 °C. Their coordination polyhedra have the composition [NiO2N2 ] and square-planar geometry. It was shown that the Ni(II) complexes demonstrate the moderate or high level of antimicrobial activity against bacteria and fungi strains tested as well as ability to reduce cytochrome c.

Author Biographies

  • Hleb I. Harbatsevich, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

    postgraduate student at the department of inorganic chemistry, faculty of chemistry

  • Natalia V. Loginova, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

    doctor of science (chemistry), full professor; professor at the department of inorganic chemistry, faculty of chemistry

  • Kseniya A. Nabebina, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

    student at the faculty of chemistry

  • Sergei I. Stakhevich, Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk

    student at the faculty of pharmacy

  • Irina N. Slabko, Scientific Research Department of Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk

    senior researcher at the laboratory of nosocomial infections

  • Nikolai P. Osipovich, Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

    PhD (chemistry); senior researcher

  • Galina A. Ksendzova, Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

    PhD (chemistry); senior researcher

  • Igor I. Azarko, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

    PhD (physics and mathematics), docent; associate professor at the department of semiconductor physics and nanoelectronics, faculty of physics

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Published

2017-11-29

Issue

No. 1 (2017): Journal of the Belarusian State University. Chemistry

Section

Original Articles

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How to Cite

[1]
Harbatsevich, H.I. et al. 2017. Bioactive Ni(II) complexes with catechol derivatives. Journal of the Belarusian State University. Chemistry. 1 (Nov. 2017), 58–64.