Features of diadenosine tetraphosphate influence on thrombininduced platelet aggregation of pregnant women with preeclampsia

Authors

  • Andrei V. Bakunovich Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus
  • Olga D. Bichan Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Leonid M. Lobanok Belarusian State Medical University, Dzerzhinski аvenue, 83, 220116, Minsk, Belarus
  • Klavdiya Ya. Bulanova Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

Keywords:

pre-eclampsia, platelets, aggregation, thrombin, diadenosine tetraphosphate

Abstract

Pregnant women with pre-eclampsia have a significant increase in the degree of platelet aggregation in response to thrombin, in comparison with a physiologically occurring pregnancy. In vitro experiments revealed that diadenosine-5',5'''-P1,P4-tetraphosphate (Ap4A) reduces the degree and rate of thrombin-induced platelet aggregation in pregnant women with preeclampsia. Ap4A can be recommended as a substrate for the development of drugs aimed at reducing the increased functional activity of platelets in pre-eclampsia.

Author Biographies

  • Andrei V. Bakunovich, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

    senior lecturer of the department of ecological chemistry and biochemistry, faculty of environmental medicine

  • Olga D. Bichan, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

    head of the laboratory of the department of biophysics, faculty of physics

  • Leonid M. Lobanok, Belarusian State Medical University, Dzerzhinski аvenue, 83, 220116, Minsk, Belarus

    doctor of sciences (medical), corresponding member of the National Academy of Sciences of Belarus, full professor; professor at the department of normal physiology

  • Klavdiya Ya. Bulanova, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

    PhD (biology), associate professor; associate professor of the department of ecological chemistry and biochemistry, faculty of environmental medicine

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Published

2019-03-02

Issue

No. 2 (2018): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Bakunovich, A.V. et al. 2019. Features of diadenosine tetraphosphate influence on thrombininduced platelet aggregation of pregnant women with preeclampsia. Journal of the Belarusian State University. Ecology. 2 (Mar. 2019), 71–78.