Responces of identified cardioregulatory neurons within CNS of mollusc Lymnaea stagnalis at hyperglycemia and insulin action

  • Alexander V. Sidorov Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus https://orcid.org/0000-0002-1711-7868
  • Victoria N. Shadenko Republican Research and Practice Center for Mental Health, 152 Daŭhinaŭski Tract, Minsk 220053, Belarus
  • Victor B. Kazakevich Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
DOI: https://doi.org/10.33581/2521-1722-2019-3-49-58

Abstract

Increase in haemolymph glucose level (from 0,09 (0,08; 0,10) to 0,54 (0,44; 0,69) mmol/L) and intracavitary injection of insulin (0,05 IU/g) results in 10 –20 % growth of heart rate in comparison with control group. Multidirectional effects of glucose (10 mmol/L) and insulin (0,2 IU) – 1,6-time increase and 2,3-time decrease of firing rate respectively, were observed in identified peptide-containing neurons V.D.1 and R.Pa.D.2. Both these substances initiate the appearance of synaptic inputs on the membrane of the R.Pa.D.1 neuron, being the evidence of the central cardioregulatory rhythm activation within CNS of Lymnaea. It is assumed that shifts of glucose level are involved in neuronal cardioregulation in molluscs.

Author Biographies

Alexander V. Sidorov, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

doctor of science (biology), full professor; professor at the department of human and animal physiology, faculty of biology

Victoria N. Shadenko, Republican Research and Practice Center for Mental Health, 152 Daŭhinaŭski Tract, Minsk 220053, Belarus

researcher at the laboratory of clinical and epidemiological research

Victor B. Kazakevich, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

PhD (biology), docent; associate professor at the department of human and animal physiology, faculty of biology

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Published
2019-11-01
Keywords: electrical activity; heart; glucose; insulin, electrical activity, heart, glucose, insulin
Supporting Agencies This research has been financially supported by the Belarusian Republican Foundation for Fundamental Research (project No. B07K-41) and also by State Program for Scientific Research «Convergence-2020» (task 3.10.2).
How to Cite
Sidorov, A. V., Shadenko, V. N., & Kazakevich, V. B. (2019). Responces of identified cardioregulatory neurons within CNS of mollusc Lymnaea stagnalis at hyperglycemia and insulin action. Experimental Biology and Biotechnology, 3, 49-58. https://doi.org/10.33581/2521-1722-2019-3-49-58
Issue
No 3 (2019): Journal of the Belarusian State University. Biology
Section
Cell Biology and Physiology

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