Influence of propionic and butyric acids on lipid peroxidation in rat brain and liver homogenates

  • Elizaveta V. Yatskevich Belarusian State Medical University, 83 Dziaržynskaha Avenue, Minsk 220116, Belarus
  • Marianne Jawad Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Sergei V. Fedorovich Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
DOI: https://doi.org/10.33581/2957-5060-2023-1-26-32

Abstract

Gut microbiota can contribute to pathogenesis of different brain diseases. It is believed that strains which produced propionic acid have neurotoxic influence. Also strains which produced butyric acid have neuroprotective influence. In present paper we compare effects of propionic and butyric acids in concentration 1–10 mmol/L on basal level of lipid peroxydation and lipid peroxidation in case of oxidative stress induced by hydrogen peroxide in brain and liver homogenates. Propionic acid does not influence basal level of lipid peroxidation in brain homogenate and inhibits it in liver homogenate. Butyric acid induced this process in liver and brain homogenates. Effect was more pronounced in liver homogenate. Already 1 mmol/L of butyrate increase lipid peroxidation in 2.35 folds in this tissue. Propionic acid in concentration 10 mmol/L leads to increase lipid peroxidation induced by hydrogen peroxide in brain homogenate. The same compounds in concentration 1 and 10 mmol/L to increase lipid peroxidation in case of oxidative stress induced by hydrogen peroxide in liver homogenate. Butyric acid in concentration 5 mmol/L leads to small increase of the same characteristic in brain homogenate, 10 mmol/L of butyrate decreases lipid peroxidation induced by hydrogen peroxide in liver homogenate. Therefore, propionic and butyric acids able to influenced lipid peroxidation in brain and liver homogenates. Propionic acid mainly has antioxidant properties. Butyric acid has prooxidant properties. All effects were more pronounced in liver homogenate.

Author Biographies

Elizaveta V. Yatskevich, Belarusian State Medical University, 83 Dziaržynskaha Avenue, Minsk 220116, Belarus

trainee lecturer at the department of normal physiology

Marianne Jawad, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

master’s degree student at the department of biochemistry, faculty of biology

Sergei V. Fedorovich, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

PhD (biology), docent; associate professor at the department of biochemistry, faculty of biology

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Published
2023-02-20
Keywords: microbiota, propionic acid, butyric acid, brain, lipid peroxidation, reactive oxygen species
Supporting Agencies This work was supported by a grant from the rector of the Belarusian State University.
How to Cite
Yatskevich, E. V., Jawad, M., & Fedorovich, S. V. (2023). Influence of propionic and butyric acids on lipid peroxidation in rat brain and liver homogenates. Experimental Biology and Biotechnology, 1, 26-32. https://doi.org/10.33581/2957-5060-2023-1-26-32
Issue
No 1 (2023): Experimental Biology and Biotechnology
Section
Biochemistry

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