Bioactive Ni(II) complexes with catechol derivatives

  • Hleb I. Harbatsevich Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Natalia V. Loginova Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Kseniya A. Nabebina Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Sergei I. Stakhevich Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk
  • Irina N. Slabko Scientific Research Department of Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk
  • Nikolai P. Osipovich Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk
  • Galina A. Ksendzova Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk
  • Igor I. Azarko Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

Abstract

The complexation process of Ni(II) ions with catechol derivatives in water-ethanol medium was investigated. It was found potentiometrically that complexes with the ratio M : L = 1 : 2 were formed in solution, their overall stability constants were equal to 7,9 ⋅ 1014 – 1,6 ⋅ 1015. The Ni(II) complexes synthesized were shown to be amorphous, neutral, and thermally stable up to 150 °C. Their coordination polyhedra have the composition [NiO2N2 ] and square-planar geometry. It was shown that the Ni(II) complexes demonstrate the moderate or high level of antimicrobial activity against bacteria and fungi strains tested as well as ability to reduce cytochrome c.

Author Biographies

Hleb I. Harbatsevich, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

postgraduate student at the department of inorganic chemistry, faculty of chemistry

Natalia V. Loginova, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

doctor of science (chemistry), full professor; professor at the department of inorganic chemistry, faculty of chemistry

Kseniya A. Nabebina, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

student at the faculty of chemistry

Sergei I. Stakhevich, Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk

student at the faculty of pharmacy

Irina N. Slabko, Scientific Research Department of Belarusian State Medical University, Dzerzhinskogo avenue, 83, 220116, Minsk

senior researcher at the laboratory of nosocomial infections

Nikolai P. Osipovich, Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

PhD (chemistry); senior researcher

Galina A. Ksendzova, Research Institute for Physical Chemical Problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

PhD (chemistry); senior researcher

Igor I. Azarko, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

PhD (physics and mathematics), docent; associate professor at the department of semiconductor physics and nanoelectronics, faculty of physics

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Published
2017-11-29
Keywords: Ni(II) complexes, catechol derivatives, cytochrome c reduction, antimicrobial activity
How to Cite
Harbatsevich, H. I., Loginova, N. V., Nabebina, K. A., Stakhevich, S. I., Slabko, I. N., Osipovich, N. P., Ksendzova, G. A., & Azarko, I. I. (2017). Bioactive Ni(II) complexes with catechol derivatives. Journal of the Belarusian State University. Chemistry, 1, 58-64. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/1158
Issue
No 1 (2017): Journal of the Belarusian State University. Chemistry
Section
Original Articles

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