Stabilization of the silver(I) complex with 2-(4,6-di-tert-butyl-2,3-dihydroxyphenylsulfanyl) acetic acid in the antimicrobial dosage form

  • Hleb I. Harbatsevich Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Siarhei I. Stakhevich Belarusian State Medical University, Dziaržynskaha Avenue, 83, 220116, Minsk
  • Natalia V. Loginova Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Nikolai P. Osipovich Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk
  • Irina N. Slabko Central Research Laboratory of Belarusian State Medical University, Dziaržynskaha Avenue, 83, 220116, Minsk
  • Galina A. Ksendzova Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

Abstract

The influence of physico-chemical factors on the stability of the silver(I) complex with 2-(4,6-di-tert-butyl-2,3-dihydroxyphenylsulfanyl)acetic acid in the ointment composition based on methylcellulose hydrogel has been studied. The substance is shown to be stable provided the following conditions are fulfilled: 1) propylene glycol is used as a solvent; 2) citric acid is introduced into the ointment base of (down to pH = 4 –5) and polyvinylpyrrolidone (PVP) is added at a concentration of 5 %. The samples of ointments stable in storage are prepared, their antimicrobial activity exceeding that of «Dermazin» cream used in medical practice.

Author Biographies

Hleb I. Harbatsevich, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

postgraduate student at the department of inorganic chemistry, faculty of chemistry

Siarhei I. Stakhevich, Belarusian State Medical University, Dziaržynskaha Avenue, 83, 220116, Minsk

student at the faculty of pharmacy

Natalia V. Loginova, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

doctor of science (chemistry); professor at the department of inorganic chemistry, faculty of chemistry

Nikolai P. Osipovich, Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

PhD (chemistry); senior researcher at the laboratory of chemistry of free radical processes

Irina N. Slabko, Central Research Laboratory of Belarusian State Medical University, Dziaržynskaha Avenue, 83, 220116, Minsk

senior researcher at the laboratory of nosocomial infections

Galina A. Ksendzova, Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk

PhD (chemistry); senior researcher at the laboratory of chemistry of free radical processes

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Published
2017-12-01
Keywords: silver(I) complex, hydrogel, methylcellulose, antimicrobial activity
How to Cite
Harbatsevich, H. I., Stakhevich, S. I., Loginova, N. V., Osipovich, N. P., Slabko, I. N., & Ksendzova, G. A. (2017). Stabilization of the silver(I) complex with 2-(4,6-di-tert-butyl-2,3-dihydroxyphenylsulfanyl) acetic acid in the antimicrobial dosage form. Journal of the Belarusian State University. Chemistry, 2, 59-67. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/1168
Issue
No 2 (2017): Journal of the Belarusian State University. Chemistry
Section
Original Articles

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