Biopharmaceutical aspects of techno­logy of wound­healing gels containing silver(I) complex with 2-­(4,6-­di-­tert-­butyl-­2,3-­dihydroxyphenylsulphanyl)acetic acid

  • Hleb I. Harbatsevich Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Sergei I. Stakhevich Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Natalia V. Loginova Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Galina A. Ksendzova Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Nikolai P. Osipovich Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Irina N. Slabko Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus
  • Vasily V. Butkevich Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus
  • Zhanna A. Makarevich Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus
  • Lyudmila V. But’ko Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus

Abstract

The object of the work is to develop optimal composition of a gel with wound­healing ability based on Ag(I) complex with 2­(4,6­di­tert­butyl­2,3­dihydroxyphenylsulphanyl)acetic acid to produce a novel effective remedy. It was found that propylene glycol (PG) favours the formation of more fine suspension of Ag(I) complex, and introduction of polyvinylpyrrolidone (PVP) hinders aggregation of the particles of the complex, thus providing optimal dispersity of the gel suspension. The gels based on methyl cellulose (MC) are characterized by an acceptable degree of release of Ag(I) complex. It is the gels containing PG and PVP that are characterized by the most complete release of the active substance, which is in agreement with the data on the optimal dispersity. It was found that PG and PVP being introduced into the gel composition increase the osmotic activity of the gel considerably. The optimal composition of the ointment base was determined, %: MC – 3.5; PVP – 5.0; 0.1 mol/L citric acid solution – 5.0; PG – 20.0; water for injections – up to 100.0. The gel obtained was shown to surpass «Dermazin» cream and «Levomecol» ointment in wound­healing ability, while the content of the active substance was significantly lower (0.5 %), and to promote wounds to be cleansed of microorganisms fast and completely too. No accumulation of silver in the liver was found when the gel was used medicinally.

Author Biographies

Hleb I. Harbatsevich, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

PhD (chemistry); associate professor at the department of radiation chemistry and chemical technology, faculty of chemistry

Sergei I. Stakhevich, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

master’s degree course student at the de­partment of inorganic chemistry, faculty of chemistry

Natalia V. Loginova, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

doctor of science (chemistry), full profes­sor; professor at the department of inorganic chemistry, faculty of chemistry

Galina A. Ksendzova, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry); senior researcher at the laboratory of chemistry of free radical processes

Nikolai P. Osipovich, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry); senior researcher at the laboratory of chemistry of free radical processes

Irina N. Slabko, Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus

senior researcher at the laboratory of nosoco­mial infections

Vasily V. Butkevich, Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus

junior researcher at the laboratory of no­socomial infections

Zhanna A. Makarevich, Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus

head of experimental biological clinic (vivarium)

Lyudmila V. But’ko, Belarusian State Medical University, 83 Dzjarzhynskaga Avenue, Minsk 220089, Belarus

PhD (veterinary medicine); veterinarian of the experimental biological clinic (vivarium)

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Published
2019-08-29
Keywords: silver(I) complex, hydrogel, methyl cellulose, rheological properties, release of the active ingredient, wound-­healing ability
How to Cite
Harbatsevich, H. I., Stakhevich, S. I., Loginova, N. V., Ksendzova, G. A., Osipovich, N. P., Slabko, I. N., Butkevich, V. V., Makarevich, Z. A., & But’ko, L. V. (2019). Biopharmaceutical aspects of techno­logy of wound­healing gels containing silver(I) complex with 2-­(4,6-­di-­tert-­butyl-­2,3-­dihydroxyphenylsulphanyl)acetic acid. Journal of the Belarusian State University. Chemistry, 2, 29-39. https://doi.org/10.33581/2520-257X-2019-2-29-39