Fluorescein dihexanoate as a profluorescent marker for monitoring of hydrolytic descruction of polylactide-based materials

  • Dmitry A. Belov Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus https://orcid.org/0000-0002-0304-256X
  • Yaroslav V. Faletrov Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Polina S. Yakovets Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus
  • Vladimir M. Shkumatov Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
DOI: https://doi.org/10.33581/2520-257X-2022-1-53-60

Abstract

Polylactide (PLA) is one of the most promising biodegradable and biocompatible polymer materials. Estimation of hydrolytic destruction of PLA is of high importance for their applications both at planning and at real-time exploitation. This paper reports on synthesis and applicability of fluorescein-O-dihexanoate as a pro-fluorescent marker of hydrolytic destruction of two types of PLA-based materials. Fluorescence enhancement correlated with adequately more fast destruction of poly-D,L-lactide as well as less stability to alkaline hydrolysis. Thus, applicability of fluorescein-O-dihexanoate for fluorescence-based estimation of hydrolytic destruction of PLA-based materials is shown in quite real time mode.

Author Biographies

Dmitry A. Belov, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

PhD (chemistry); associate professor at the department of macromolecular compounds, faculty of chemistry

Yaroslav V. Faletrov, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry), docent; associate professor at the department of macromolecular compounds, faculty of chemistry, Belarusian State University, and leading researcher at the laboratory of biochemistry of drugs, Research Institute for Physical Chemical Problems, Belarusian State University

Polina S. Yakovets, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus

student at the faculty of chemistry

Vladimir M. Shkumatov, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

corresponding member of the National Academy of Sciences of Belarus, doctor of science (biology), full professor; professor at the department of macromolecular compounds, faculty of chemistry, Belarusian State University, and chief researcher at the laboratory of biochemistry of drugs, Research Institute for Physical Chemical Problems, Belarusian State University

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Published
2022-04-06
Keywords: poly-L-lactide, poly-D,L-lactide, fluorescein-O-dihexanoate, fluorescence, hydrolysis
Supporting Agencies The work was supported by governmental program of scientific researches «Chemical processes, reagents and technologies, bioregulators and bioorgchemistry» (No. 20210560).
How to Cite
Belov, D. A., Faletrov, Y. V., Yakovets, P. S., & Shkumatov, V. M. (2022). Fluorescein dihexanoate as a profluorescent marker for monitoring of hydrolytic descruction of polylactide-based materials. Journal of the Belarusian State University. Chemistry, 1, 53-60. https://doi.org/10.33581/2520-257X-2022-1-53-60
Issue
No 1 (2022): Journal of the Belarusian State University. Chemistry
Section
Original Articles

Copyright (c) 2022 Journal of the Belarusian State University. Chemistry

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