Synthesis of new multitope tetrazole-containing ligands

  • Evgeny Y. Grigoriev Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Ludmila S. Ivashkevich Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Alexander S. Lyakhov Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Inna M. Grigorieva Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Yuri V. Grigoriev Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus https://orcid.org/0000-0002-8153-835X
  • Oleg A. Ivashkevich Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
DOI: https://doi.org/10.33581/2520-257X-2022-2-19-29

Abstract

Drawing the experience of 5-phenyl- and 5-pyridyltetrazoles, it was shown that classical nitration-reduction methods in combination with typical alkylation reactions of tetrazole derivatives can be used to obtain multitopic polynuclear tetrazole-containing ligands. Methods for the preparation of a number of previously undescribed polynuclear tetrazole derivatives, including those combining both tetrazole and pyridine rings in the molecule, have been developed. The composition and structure of the obtained compounds were determined by elemental analysis, single crystal X-ray diffraction, NMR and IR spectroscopy. For (5-(pyridin-2-yl)tetrazol-2-yl)(5-(pyridin-2-yl)tetrazol-1-yl)methane the crystalline structure was determined and it was found that this compound forms a 3D polymer framework due to non-classical hydrogen bonds. In its crystal structure there is a network of π – π stacking interactions between tetrazole rings of neighbouring molecules, as well as between pyridine rings.

Author Biographies

Evgeny Y. Grigoriev, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

junior researcher at the laboratory for chemistry of condensed systems

Ludmila S. Ivashkevich, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry), docent; head of the laboratory of physico-chemical investigations

Alexander S. Lyakhov, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry), docent; leading researcher at the laboratory for chemistry of condensed systems

Inna M. Grigorieva, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

researcher at the laboratory for chemistry of condensed systems

Yuri V. Grigoriev, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry), docent; head of the laboratory for chemistry of condensed systems

Oleg A. Ivashkevich, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

academician of the National Academy of Sciences of Belarus, doctor of science (chemistry), full professor; chief researcher at the laboratory for chemistry of condensed systems

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Published
2022-08-23
Keywords: 5-substituted tetrazoles, functionalisation, polynuclear derivatives, synthesis, single crystal X-ray diffraction, NMR spectroscopy, IR spectroscopy
Supporting Agencies The research was supported by the Ministry of Education of the Republic of Belarus (assignment 2.1.01.01 of the state program of scientific research «Chemical processes, reagents and technologies, bioregulators and bioorgchemistry»).
How to Cite
Grigoriev, E. Y., Ivashkevich, L. S., Lyakhov, A. S., Grigorieva, I. M., Grigoriev, Y. V., & Ivashkevich, O. A. (2022). Synthesis of new multitope tetrazole-containing ligands. Journal of the Belarusian State University. Chemistry, 2, 19-29. https://doi.org/10.33581/2520-257X-2022-2-19-29
Issue
No 2 (2022): Journal of the Belarusian State University. Chemistry
Section
Original Articles

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