Extraction of cannabinoids by hexane from polar organic solvents and their mixtures with water

  • Olga N. Mikhniuk State Institute for Advanced Studies and Retraining of Personnel of Customs Bodies of the Republic of Belarus, 45/4 Magiliowskaja Street, Minsk 220007, Belarus
  • Sergey M. Leschev Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Mikhail F. Zayats Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Dmitry S. Kypchenya State Forensic Examination Committee of the Republic of Belarus, 43 Kalvaryjskaja Street, Minsk 220073, Belarus
  • Yana L. Nikandrava State Institute for Advanced Studies and Retraining of Personnel of Customs Bodies of the Republic of Belarus, 45/4 Magiliowskaja Street, Minsk 220007, Belarus
  • Ruslan A. Yurchenko Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

Abstract

Distribution constants of cannabidiol, cannabinol and tetrahydrocannabinol in systems hexane – polar organic solvents (methanol, ethanol, propylene glycol, ethylene glycol, diethylene glycol, 2-methoxyethanol, dimethyl sulfoxide, dimethylformamide, acetonitrile) and hexane – aqueous organic mixtures were determined experimentally. Gas chromatography with mass spectrometric detection was used to determine the concentrations of substances in solutions. Based on the obtained data, a sample preparation technique for determining cannabinoids in objects of plant origin was proposed.

Author Biographies

Olga N. Mikhniuk, State Institute for Advanced Studies and Retraining of Personnel of Customs Bodies of the Republic of Belarus, 45/4 Magiliowskaja Street, Minsk 220007, Belarus

PhD (chemistry); chief expert at the customs laboratory

Sergey M. Leschev, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

doctor of science (chemistry), full professor; professor at the department of analytical chemistry, faculty of chemistry

Mikhail F. Zayats, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

doctor of science (chemistry), docent; head of the department of analytical chemistry, faculty of chemistry

Dmitry S. Kypchenya, State Forensic Examination Committee of the Republic of Belarus, 43 Kalvaryjskaja Street, Minsk 220073, Belarus

expert at the drug research department, directorate of physical-chemical and explosive examination, general directorate of special examination, central office

Yana L. Nikandrava, State Institute for Advanced Studies and Retraining of Personnel of Customs Bodies of the Republic of Belarus, 45/4 Magiliowskaja Street, Minsk 220007, Belarus

head of the customs laboratory

Ruslan A. Yurchenko, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

senior lecturer at the department of analytical chemistry, faculty of chemistry

References

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Published
2024-08-16
Keywords: cannabinoids, distribution constants, extraction sample preparation, gas chromatography, mass spectrometry
How to Cite
Mikhniuk, O. N., Leschev, S. M., Zayats, M. F., Kypchenya, D. S., Nikandrava, Y. L., & Yurchenko, R. A. (2024). Extraction of cannabinoids by hexane from polar organic solvents and their mixtures with water. Journal of the Belarusian State University. Chemistry, 2, 53-60. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/6474
Issue
No 2 (2024): Journal of the Belarusian State University. Chemistry
Section
Original Articles

Copyright (c) 2024 Journal of the Belarusian State University. Chemistry

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