Highly sensitive ion-exchanger based polyvinyl chloride membrane sensor for determination of vinpocetine and its use in drugs analysis

  • Faisal Abdula Salih College of Health and Medical Technology, Sulaimani Polytechnic University, 44 Zewar Street, Sulaymaniyah, Kurdistan Region, Iraq; Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Andrei D. Novakovskii Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieningradskaja Street, Minsk 220006, Belarus
  • Yulia G. Zaitseva Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus
  • Vladimir V. Egorov Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieningradskaja Street, Minsk 220006, Belarus

Abstract

It has been established that the correct choice of the ion-exchanger, plasticiser and the measurement conditions makes it possible to achieve analytical characteristics of vinpocetine-sensitive electrodes based on commercially available components, far superior to those described in the literature. It has been found, that the effect of pH on the vinpocetine-sensitive electrodes response takes place in much more acidic media than might be expected from protolytic equilibrium and is due to the extraction of the molecular form of vinpocetine into the membrane phase from both external and inner solutions. Very good parameters of selectivity (from –7.4 to – 9.8 in respect to inorganic ions), lower detection limit (1.7 ⋅ 10–7 mol ⋅ L–1), linear response range (1.0 ⋅ 10– 6 mol ⋅ L–1), and potential reproducibility (± 0.06 mV in 1.0 ⋅ 10– 4 mol ⋅ L–1 solution of vinpocetine) are achieved using 2-nitrophenyl octyl ether as a plasticiser, potassium tetrakis(4-chlorophenyl)borate as an ion-exchanger and creating conditions that exclude non-exchangable extraction of vinpocetine into the membrane at the stages of both conditioning the electrode and performing measurements. Methods for the determination of vinpocetine in dosage forms (pills and solutions for injections) using both direct potentiometry and potentiometric titration techniques characterised by simplicity, rapidity and high metrological characteristics have been proposed.

Author Biographies

Faisal Abdula Salih, College of Health and Medical Technology, Sulaimani Polytechnic University, 44 Zewar Street, Sulaymaniyah, Kurdistan Region, Iraq; Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

director of health and safety, College of Health and Medical Technology, Sulaimani Polytechnic University, and postgraduate student at the department of analytical chemistry, faculty of chemistry, Belarusian State University



Andrei D. Novakovskii, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieningradskaja Street, Minsk 220006, Belarus

PhD (сhemistry), docent; docent of the department of analytical chemistry, faculty of сhemistry, Belarusian State University, and senior researcher at the laboratory of physico-chemical methods of investigation, Research Institute for Physical Chemical Problems, Belarusian State University

Yulia G. Zaitseva, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus

student at the faculty of chemistry

 

Vladimir V. Egorov, Belarusian State University, 4 Niezaliezhnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieningradskaja Street, Minsk 220006, Belarus

doctor of science (chemistry), full professor; professor at the department of analytical chemistry, faculty of chemistry, Belarusian State University, and chief researcher at the laboratory of physicochemical investigations, Research Institute for Physical Chemical Problems, Belarusian State University

 

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Published
2024-03-15
Keywords: potentiometry, ion-selective electrode, vinpocetine, lipophilic physiologically active amines, pharmaceutical analysis
Supporting Agencies This research was supported by the Ministry of Education of the Republic of Belarus (assignment 2.1.01.02/2 of the state programme of scientific research «Chemical technologies, processes and reagents», state registration No. 20210513).
How to Cite
Salih, F. A., Novakovskii, A. D., Zaitseva, Y. G., & Egorov, V. V. (2024). Highly sensitive ion-exchanger based polyvinyl chloride membrane sensor for determination of vinpocetine and its use in drugs analysis. Journal of the Belarusian State University. Chemistry, 1, 33-45. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/6034