Structural and functional alterations of platelets in pregnant women with preeclampsia

Authors

  • Andrei V. Bakunovich Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Republic of Belarus
  • Klavdia Ya. Bulanova Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Republic of Belarus

Keywords:

preeclampsia, platelets, aggregation, thrombin, ADP, thromboxane A2, calcium

Abstract

The article presents the characteristics of platelets in normal and pathological conditions of pregnancy. The functional state of platelets, especially regulation of their count, reorganization of plasma membrane and intracellular structures, as well as ability of cells to activate in physiological condition and during preeclampsia, are described. The mechanisms of increased platelet aggregation activity in pregnant women with preeclampsia due to changes in the composition of their plasma membranes, intracellular organelles, changes in the content of cytoplasmic calcium, thromboxane A2 and their correlations with other intracellular messengers are considered.

Author Biographies

  • Andrei V. Bakunovich, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Republic of Belarus

    senior lecturer of the department of ecological chemistry and biochemistry

  • Klavdia Ya. Bulanova, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Republic of Belarus

    PhD (biological), associate professor; associate professor of the department of ecological chemistry and biochemistry

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Published

2019-03-02

Issue

No. 4 (2018): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Bakunovich, A.V. and Bulanova, K.Y. 2019. Structural and functional alterations of platelets in pregnant women with preeclampsia. Journal of the Belarusian State University. Ecology. 4 (Mar. 2019), 76–83.