Analysis of physicochemical characteristics of blood cell membranes of patients with rheumatoid arthritis

Authors

  • Irina V. Puhteeva International Sakharov Environmental Institute, Belarusian State University
  • Alesia V. Kaurova International Sakharov Environmental Institute, Belarusian State University
  • Natalya V. Gerasimovich International Sakharov Environmental Institute, Belarusian State University https://orcid.org/0000-0002-4285-6718
  • Mark L. Levin International Sakharov Environmental Institute, Belarusian State University https://orcid.org/0000-0002-9775-6693
  • Ludmila A. Malkevich Belarusian State Medical University image/svg+xml

Keywords:

rheumatoid arthritis, peripheral blood lymphocytes, erythrocytes, plasma membrane, pyrene, polarity, microviscosity

Abstract

In the work reviewed and analyzed the results reflecting the physical and chemical state of the lymphocyte membranes of patients with rheumatoid arthritis. It was found that patients with rheumatoid arthritis did not show significant changes in the polarity of different areas of the membrane. At the same time discovered that annular lipid microviscosity of the plasma membrane of lymphocytes in patients with rheumatoid arthritis is reduced 2.5 times compared to control values in healthy patients, and the increased microviscosity in the general area of lipid bilayer was increased this by 25 % in relation to control values. The value of the degree of quenching of tryptophan fluorescence by pyrene in patients with rheumatoid arthritis is reduced by 35 % in relation to the control. In the membranes of red blood cells of patients with rheumatoid arthritis, there were no significant differences compared with the control values.

Author Biographies

  • Irina V. Puhteeva, International Sakharov Environmental Institute, Belarusian State University

    senior lecturer at the department of environmental medicine and radiobiology

  • Alesia V. Kaurova, International Sakharov Environmental Institute, Belarusian State University

    student of 4th year at the faculty of environmental medicine

  • Natalya V. Gerasimovich, International Sakharov Environmental Institute, Belarusian State University

    PhD (biology), docent; associate professor at the department of environmental medicine and radiobiology

  • Mark L. Levin, International Sakharov Environmental Institute, Belarusian State University

    PhD (physics and mathematics), docent; associate professor at the department of environmental medicine and radiobiology

  • Ludmila A. Malkevich, Belarusian State Medical University

     PhD (medicine), docent; head of the department of medical rehabilitation and physiotherapy

Published

2022-01-06

Issue

No. 3 (2021): Journal of the Belarusian State University. Ecology.

Section

Medical Ecology

How to Cite

[1]
Puhteeva, I.V. et al. 2022. Analysis of physicochemical characteristics of blood cell membranes of patients with rheumatoid arthritis. Journal of the Belarusian State University. Ecology. 3 (Jan. 2022), 66–72.