Influence of β-cyclodextrin derivatives on the bioavailability and biodistribution of tetrapyrrole compounds

Authors

  • Ilya V. Yakavets Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Research Centre for Automatic Control of Nancy, University of Lotaringia, Science Campus, 54500, Vandovr-Nanci, France; Lorraine Institute of Oncology, Burgundy avenue, 6, 54519, Vandovr-Nanci, France
  • Igor v. Yankovsky Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Kiryl N. Barysau Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Konstantin A. Jukov Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Mikhail V. Belevtsev Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Frunzenskaya Street, 43, der. Borovlyany, 223053, Minsk Region, Belarus
  • Lina N. Bolotine Research Centre for Automatic Control of Nancy, University of Lotaringia, Science Campus, 54500, Vandovr-Nanci, France; Lorraine Institute of Oncology, Burgundy avenue, 6, 54519, Vandovr-Nanci, France
  • Vladimir P. Zorin Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Belarusian State University, International Sakharov Environmental Institute Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

Keywords:

temoporfin, photosensitizer, inclusion complexes, cyclodextrins, biodistribution
Supporting Agencies
This work was supported by Belarusian Republican Foundation for Fundamental Research (BRFFR) (projects number № M16M-049 and № M17MС-028), Institut de Cancérologie de Lorraine, French «Ligue Nationale contre le Cancer (CCIR-GE)». The authors thank biolitec research GmbH (Jena, Germany) for providing mTHPC.

Abstract

Due to their unique properties, drug delivery systems based on cyclodextrins are very popular and promising for the development of new drug formulations. Previously, it has been found that cyclodextrins have a high affinity to the aryl substituted tetrapyrrolic compounds which in turn are effective sensitizers for photodynamic therapy. Of special interest for this study is the investigation of β-cyclodextrins (β-CDs) effect on bioavailability and biodistribution of tetrapyrrolic photosensitizer temoporfin (mTHPC) in various biological systems. It was showed that association of mTHPC with the β-CDs completely abolishes its aggregation after introduction into blood serum. Kinetic and equilibrium distribution of mTHPC between β-CDs and serum were studied by means of special fluorescent technique. β-CDs increase diffusion movement of mTHPC molecules between biological structures such as serum proteins. It was demonstrated that the β-CDs have a concentration-dependent effect on the process of mTHPC distribution in blood serum and accumulation in blood cells. The results obtained suggest a significant effect of β-CD molecules on the penetration and distribution of mTHPC in tumor tissue, as well as indicate the possibility of using β-CD to reduce the risk of photoallergic reactions during photodynamic therapy with mTHPC.

Author Biographies

  • Ilya V. Yakavets, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Research Centre for Automatic Control of Nancy, University of Lotaringia, Science Campus, 54500, Vandovr-Nanci, France; Lorraine Institute of Oncology, Burgundy avenue, 6, 54519, Vandovr-Nanci, France

    junior researcher at the laboratory of biophysics and biotechnology, post-graduate student at the department of biophysics

  • Igor v. Yankovsky, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

     doctor of science (philosophy); assistant of the department of common physics

  • Kiryl N. Barysau, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

     student of the faculty of physics

  • Konstantin A. Jukov, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

     student of the faculty of physics

  • Mikhail V. Belevtsev, Belarusian Research Center for Pediatric Oncology, Hematology and Immunology, Frunzenskaya Street, 43, der. Borovlyany, 223053, Minsk Region, Belarus

    PhD (biology), associate professor; deputy director for scientific work

  • Lina N. Bolotine, Research Centre for Automatic Control of Nancy, University of Lotaringia, Science Campus, 54500, Vandovr-Nanci, France; Lorraine Institute of Oncology, Burgundy avenue, 6, 54519, Vandovr-Nanci, France

    doctor of science (philosophy), doctor of science (medicine); head of research department

  • Vladimir P. Zorin, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Belarusian State University, International Sakharov Environmental Institute Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

    PhD (biology) associate professor; head of the laboratory of biophysics and biotechnology

Downloads

Published

2018-03-04

Issue

No. 3 (2017): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Yakavets, I.V. et al. 2018. Influence of β-cyclodextrin derivatives on the bioavailability and biodistribution of tetrapyrrole compounds. Journal of the Belarusian State University. Ecology. 3 (Mar. 2018), 81–90.