Synthesis of esters of emoxypine

Authors

  • Maryna V. Лисовская Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, 5/2 Academic V. F. Kuprevich street, 5/2, 220141, Minsk, Belarus
  • Evgeny I. Kvasyuk Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

Keywords:

emoxypine, 2-ethyl-6-methylpyridine-3-ol, hydroxypyridine, lipophilic derivatives, spectroscopy

Abstract

A new and effective method for preparation of esters of emoxypine as potentially having increased permeability of the Blood-Brain Barrier was developed. Some new (2-ethyl-6-methylpyridine-3-yl)butandioat derivatives 13–16 were obtained by condensation of emoxypine 3 with previously synthesized n-butyl, n-amyl, i-amyl and benzyl monoesters of succinic acid 4, 6–8 in presence of dicyclohexycarbodiimide or by reaction of sodium salt of emoxypine with chloroanhydride of corresponding esters. The structures of synthesized compounds were confirmed by UV-, IR-, NMRspectroscopy and mass-spectrometry.

Author Biographies

  • Maryna V. Лисовская, Institute of Bioorganic Chemistry of the National Academy of Sciences of Belarus, 5/2 Academic V. F. Kuprevich street, 5/2, 220141, Minsk, Belarus

    junior researcher of the laboratory of lipids chemistry

  • Evgeny I. Kvasyuk, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

    doctor of science (chemistry), full professor of the department of environmental chemistry and biochemistry

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Published

2019-03-02

Issue

No. 4 (2018): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Лисовская M.V. and Kvasyuk, E.I. 2019. Synthesis of esters of emoxypine. Journal of the Belarusian State University. Ecology. 4 (Mar. 2019), 119–127.