Diadenosine tetraphosphate effect on the functional activity of pregnant women with pre-eclampsia at oxidative stress

Authors

  • Andrei V. Bakunovich International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus
  • Leonid M. Lobanok Belarusian State Medical University, 83 Dzjarzhinskaga Avenue, Minsk 220116, Belarus
  • Anatoly I. Zinchenko International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus; Institute of Microbiology of the National Academy of Sciences of Belarus, 2 acad. V. F. Kuprevich, Minsk 220141, Belarus
  • Klavdiya Ya. Bulanova International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

Keywords:

pre-eclampsia, platelets, aggregation, hydrogen peroxide, diadenosine tetraphosphate

Abstract

Pregnant women with pre-eclampsia have no significant increase in the degree of platelet aggregation in response to the action of hydrogen peroxide, compared with a physiologically occurring pregnancy. In vitro experiments revealed that diadenosine tetraphosphate reduces the degree and rate of platelet aggregation induced by hydrogen peroxide in pregnant women with physiologically occurring pregnancy and pre-eclampsia.

Author Biographies

  • Andrei V. Bakunovich, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

    senior lecturer at the department of ecological chemistry and biochemistry

  • Leonid M. Lobanok, Belarusian State Medical University, 83 Dzjarzhinskaga Avenue, Minsk 220116, Belarus

    corresponding member of the National Academy of Sciences of Belarus, doctor of science (medicine), full professor; professor at the department of normal physiology

  • Anatoly I. Zinchenko, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus; Institute of Microbiology of the National Academy of Sciences of Belarus, 2 acad. V. F. Kuprevich, Minsk 220141, Belarus

    corresponding member of the National Academy of Sciences of Belarus, doctor of science (biology), full professor; head of the laboratory of molecular biotechnology; professor at the department of ecological chemistry and biochemistry

  • Klavdiya Ya. Bulanova, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

    PhD (biology), docent; associate professor at the department of ecological chemistry and biochemistry

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Published

2019-08-16

Issue

No. 2 (2019): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Bakunovich, .A.V. et al. 2019. Diadenosine tetraphosphate effect on the functional activity of pregnant women with pre-eclampsia at oxidative stress. Journal of the Belarusian State University. Ecology. 2 (Aug. 2019), 60–67.