Features of the ATP and diadenosine tetraphosphate effect on ADP-induced platelet aggregation at pre-eclampsia

Authors

  • Andrei V. Bakunovich International Sakharov Environmental Institute, Belarusian State University, 23/1Dolgobrodskaya Street, Minsk 220070, Belarus https://orcid.org/0000-0002-0111-8188
  • Anatoly I. Zinchenka International Sakharov Environmental Institute, Belarusian State University, 23/1Dolgobrodskaya Street, Minsk 220070, Belarus https://orcid.org/0000-0003-2401-2586
  • Klavdiya Ya. Bulanava International Sakharov Environmental Institute, Belarusian State University, 23/1 Dolgobrodskaya Street, Minsk 220070, Belarus

Keywords:

pre-eclampsia, platelets, aggregation, ADP, ATP, diadenosine tetraphosphate

Abstract

In vitro experiments established significant increase in the aggregation degree of pregnant women platelets with pre-eclampsia in response to the action of ADP, compared with a physiological pregnancy. Experiments revealed that diadenosine-5’,5’’’-P1,P4-tetraphosphate and ATP-Mg2+ are able to exert an inhibitory effect on ADP-induced platelet aggregation during pre-eclampsia. The potential advantage of Ap4A and its derivatives as therapeutic agents is that they have a synergistic inhibitory effect on the P2Y1 and P2Y12 platelet receptors and have a longer half-life in the bloodstream compared to ATP. The research results suggest using Ap4A as a substrate for the development of drugs aimed at reducing the increased functional activity of platelets during pre-eclampsia.

Author Biographies

  • Andrei V. Bakunovich, International Sakharov Environmental Institute, Belarusian State University, 23/1Dolgobrodskaya Street, Minsk 220070, Belarus

    senior lecturer at the department of ecological chemistry and biochemistry

  • Anatoly I. Zinchenka, International Sakharov Environmental Institute, Belarusian State University, 23/1Dolgobrodskaya Street, Minsk 220070, Belarus

    professor at the department of ecological chemistry and biochemistrya

  • Klavdiya Ya. Bulanava, International Sakharov Environmental Institute, Belarusian State University, 23/1 Dolgobrodskaya Street, Minsk 220070, Belarus

    PhD (biology), docent; associate professor at the department of ecological chemistry and biochemistry

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Published

2020-04-21

Issue

No. 4 (2019): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Bakunovich, A.V. et al. 2020. Features of the ATP and diadenosine tetraphosphate effect on ADP-induced platelet aggregation at pre-eclampsia. Journal of the Belarusian State University. Ecology. 4 (Apr. 2020), 71–79.