Molecular genetic micro-RNA expression profile for skin melanoma

Authors

  • Raisa M. Smoliakova Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

Keywords:

ecological risk factors, melanoma, melanocytic nevus, micro-RNA, profile, expression

Abstract

The molecular genetic profile of the expression of oncogenic microRNA mir-21, mir-181, mir-182, mir-221, mir-222 and tumor suppressor genes mir-214, mir-200b, mir-15b in melanoma of the skin and melanocytic nevi. It is noted that an increase in the evaluation of microcancer oncogenes can be used for the differential diagnosis of skin melanoma. Reducing the levels of suppressor genes of microRNA mir-214, mir-200b, mir-15b characterizes the activation of proliferation processes, neoangiogenesis, and the progression of the tumor process.

Author Biography

  • Raisa M. Smoliakova, Belarusian State University, International Sakharov Environmental Institute, Dolgobrodskaya street, 23/1, 220070, Minsk, Belarus

    doctor of science (biology), associate professor; head of the department of general ecology, biology and environmental genetics

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Published

2019-03-03

Issue

No. 3 (2018): Journal of the Belarusian State University. Ecology

Section

Medical Ecology

How to Cite

[1]
Smoliakova, R.M. 2019. Molecular genetic micro-RNA expression profile for skin melanoma. Journal of the Belarusian State University. Ecology. 3 (Mar. 2019), 80–86.