Studying in vivo hematotropic and immunotropic properties of substances based on mycelium of mushrooms Ganoderma lucidum and Laetiporus sulfureus

Authors

  • Tatyana R. Romanovskaya International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus
  • Natalia V. Ikonnikova International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus
  • Maryna V. Lоbai International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus

Keywords:

hematotropic properties, immunotropic effect, immunotoxicity, fungal substances, Ganoderma lucidum, Laetiporus sulfureus, peritoneal microphages, delayed-type hypersensitivity, humoral immune response, species immunity

Abstract

The possible hematotropic and immunotoxic effects of substances based on the fungal mycelium with the healing properties of Ganoderma lucidum LM-8 and Laetiporus sulfureus LM-11 were studied in vivo. It is shown that these substances do not have an immunotoxic effect when used at a dose of 50 mg/kg of animal weight. It has been established that the use of a combined mushroom substation based on the L. sulfureus LM-11 and G. lucidum LM-8 mycelium in used doses causes a decrease in the number of leukocytes in the peripheral blood while maintaining their physiological level and leukocyte formula. The inhibitory effect of the combined mushroom substation on the functional activity of peritoneal macrophages was shown. The main immunotropic effect of all the investigated substances is focused on the enhancement of the cellular immune response, which is manifested as a significant increase in the hypersensitivity index of the delayed type in comparison with the control group of animals.

Author Biographies

  • Tatyana R. Romanovskaya, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus

    PhD (medicine), docent; associate professor at the department of immunology and environmental epidemiology

  • Natalia V. Ikonnikova, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus

    PhD (biology), associate professor at the department of immunology and environmental epidemiology

  • Maryna V. Lоbai, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daúhabrodskaya Street, Minsk 220070, Belarus

    PhD (medicine), docent; associate professor at the department of immunology and environmental
    epidemiology

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Published

2019-03-16

Issue

No. 1 (2019): Journal of the Belarusian State University. Ecology

Section

Industrial and Agricultural Ecology

How to Cite

[1]
Romanovskaya, T.R. et al. 2019. Studying in vivo hematotropic and immunotropic properties of substances based on mycelium of mushrooms Ganoderma lucidum and Laetiporus sulfureus. Journal of the Belarusian State University. Ecology. 1 (Mar. 2019), 76–83.