Immunological features in children with hemorrhagic vasculitis

Abstract

Currently the incidence of hemorrhagic vasculitis in children is characterized by an increase in all age groups what may be associated with environmental problems, chronic infection as well as food and drugs allergy. To date there are no biomarkers predicting the further development of hemorrhagic exanthema at the onset of the disease and followed its outcome. The quantitative and functional features of cellular and humoral immunity in children with hemorrhagic vasculitis of various origins accompanied by hemorrhagic exanthema at the onset of the disease are presented in this article. The reduction of γδТ-cells number in the peripheral blood correlated with levels of specific antineutrophil cytoplasmic antibodies and IgG EBNA-1 antibodies against a high ability of γδТ-cells to activation were established in children with systemic (immunocomplex) vasculitis. At the contrast, the background of a normal γδT-lymphocytes’ content was associated with the decrease in γδТ-cells activation capacity in children with hemorrhagic vasculitis of infectious-allergic genesis. Thus, quantitative and functional changes in γδТ-lymphocytes can be a potential labor biomarker for early diagnosis of systemic or infectious-allergic hemorrhagic vasculitis in children what may be used for the further disease course prediction.