Антиоксидантная активность гексагидрохинолонов

Ekaterina I.  Tarun; Anastasiya V.  Dankova; Anatoly N. Pyrko

Ekaterina I. Tarun International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus
Anastasiya V. Dankova International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus
Anatoly N. Pyrko International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus

Abstract

Comparative characteristics of the antioxidant properties of five different structures held hexahydroquinolones conducted. The dependence of the fluorescence intensity of fluorescein from the logarithm of the concentration of hexahydroquinolones, of which graphically determined indicators IC50. IC50 values in this series was 0,32–5,5∙10-7 М. Hexahydroquinolones have a high antioxidant activity, restoring the fluorescein fluorescence intensity to 76–94 %. An analysis of the contribution of individual functional groups, such as methoxy groups and carboethoxy groups, as well as their amounts and locations relative to each other during the binding of free radicals is done.

Author Biographies

Ekaterina I. Tarun, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus

PhD (chemistry), docent; associate professor at the department of environmental chemistry and biochemistry

Anastasiya V. Dankova, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus

student

Anatoly N. Pyrko , International Sakharov Environmental Institute, Belarusian State University, 23/1 Daйhabrodskaja Street, Minsk 220070, Belarus

PhD (chemistry), docent; associate professor at the department of environmental chemistry and biochemistry

Antioxidant activity of hexahydroquinolines

Abstract

Author Biographies