Immunohistochemical characteristics of molecular-biological subtypes of breast cancer

  • Irina N. Marchuk International Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus
  • Raisa M. Smolyakova aInternational Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus
  • Ekaterina M. Shpadaruk International Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus

Abstract

Breast cancer is a heterogeneous group of tumors that differ in morphology, clinical course and sensitivity to treatment. There are four molecular subtypes, each of which requires different treatment options, and has a different survival rate. During the immunohistochemical analysis, molecular subtypes of breast cancer were identified according to the levels of expression Her2 / neu, Ki-67, ER, PR, which must be considered to predict the course of the disease and the choice of treatment tactics for patients.

Author Biographies

Irina N. Marchuk, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus

Master's student at the department of general biology and genetics.

Raisa M. Smolyakova, aInternational Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus

Doctor of sciences (biology), full professor; professor at the department of general biology and genetics.

Ekaterina M. Shpadaruk, International Sakharov Environmental Institute, Belarusian State University, 23/1 Daŭhabrodskaja Street, Minsk 220070, Belarus

PhD (biology); associate professor at the department of general biology and genetics.

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Published
2020-04-13
Keywords: immunohistochemical analysis, breast cancer, markers, molecular subtypes
Supporting Agencies This work was financially supported by the Belarusian Republican Foundation for Basic Research (grant № М19М-015).
How to Cite
Marchuk, I. N., Smolyakova, R. M., & Shpadaruk, E. M. (2020). Immunohistochemical characteristics of molecular-biological subtypes of breast cancer. Journal of the Belarusian State University. Ecology, 3, 58-64. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/2984
Issue
No 3 (2019): Journal of the Belarusian State University. Ecology
Section
Medical Ecology

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