The role of genetic component in various types of addiction: the analysis of the results of genome-wide association studies

  • Evgeny V. Snytkov International Sakharov Environmental Institute, Belarussian State University
  • Viachaslau N. Kipen Institute of Genetics and Cytology, National Academy of Sciences of Belarus
  • Sergey B. Melnov International Sakharov Environmental Institute, Belarussian State University; The Belarusian State University of Physical Culture

Abstract

The article presents the analysis of the results of genome-wide association studies (GWAS), conducted over the past 10 years and aimed at finding genetic markers associated with increased risk of developing various types of addiction (alcoholism, drug addiction, smoking), pathological gambling and schizophrenia. For a number of diseases that have genetic markers with proven clinical significance in their etiopathogenesis: for alcohol dependence – GABRA2, ADH1B, ADH1C, TAS2R16, HTR2A genes; for drug addiction – OPRM1, OPRD1 genes; for nicotine addiction – SLC6A3, GPR51, GPR51, CYP2A6, CHRNA4 genes; for schizophrenia – SCZD12, MTHFR, CHI3L1, DISC2, SYN2, DRD3 genes, the
discovery of new polymorphic variants associated with a particular disease will allow us to identify previously not described dependencies and patterns. GWAS results will help identify possible common signaling pathways in the etiopathogenesis of the nosologies discussed in this stady.

Author Biographies

Evgeny V. Snytkov, International Sakharov Environmental Institute, Belarussian State University

teacher at the department of general biology and genetics

Viachaslau N. Kipen, Institute of Genetics and Cytology, National Academy of Sciences of Belarus

PhD (biology); researcher at the laboratory of genetic and cellular engineering

Sergey B. Melnov, International Sakharov Environmental Institute, Belarussian State University; The Belarusian State University of Physical Culture

doctor of science (biology), full professor; professor at the department of environmental medicine and radiobiologya; professor at the department of anatomyc.

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Published
2020-10-20
Keywords: alcoholism, tobacco smoking, gambling, drug addiction, schizophrenia, genetics, genome, single nucleotide polymorphism, genome-wide association studies (GWAS)
How to Cite
Snytkov, E. V., Kipen, V. N., & Melnov, S. B. (2020). The role of genetic component in various types of addiction: the analysis of the results of genome-wide association studies. Journal of the Belarusian State University. Ecology, 1, 61-75. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/3343
Issue
No 1 (2020): Journal of the Belarusian State University. Ecology
Section
Medical Ecology