Microelement composition investigation in peripheral blood and synovial fluid in osteoarthritis

  • Irina V. Koktysh International Sakharov Environmental Institute, Belarusian State University
  • Anastasia M. Bashura International Sakharov Environmental Institute, Belarusian State University
  • Vitaliy T. Koktysh 11 Minsk city clinical hospital
  • Elena I. Venskaya Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus
  • Alexsandra S. Skarabahatava Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus

Abstract

It was determined the content of osteo-associated trace elements Ca, Zn, Cu, Fe in the peripheral blood and synovial fluid in patients with confirmed clinical and radiological signs of osteoarthritis. The determination of trace elements was carried out by the ICP AES method. There were found a statistically significant iron concentration decrease (p = 0,01) and an increase of calcium (0,003) and zinc (p = 0,01) in the peripheral blood in patients with osteoarthritis. At the same time, there were established in a study of the concentration of trace elements in the synovial fluid, a statistically significant increase of iron concentration (p = 0,01) and a decrease in the concentration of calcium (p = 0,01) and zinc (p = 0,02). A direct correlation was found between the degree of osteoarthritis and the concentration of calcium in peripheral blood (Rs = 0,66, p <0,001) in gonarthrosis. Statistically significant negative correlation was found between the iron concentration in the peripheral blood and the degree of osteoarthritis in gonarthrosis (Rs = -0,57, p <0,03). Analysis of the microelement composition of synovial fluid and peripheral blood can be used in the complex diagnosis of patients with deforming joint diseases.

Author Biographies

Irina V. Koktysh, International Sakharov Environmental Institute, Belarusian State University

PhD (biology); head of environmental biotechnology laboratory

Anastasia M. Bashura, International Sakharov Environmental Institute, Belarusian State University

master’s student at the faculty of environmental medicine

Vitaliy T. Koktysh, 11 Minsk city clinical hospital

traumatologist-orthopedist of the rehabilitation department No. 4 of the 11th city clinical hospital in Minsk

Elena I. Venskaya, Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus

researcher at the institute of biophysics and cell engineering

Alexsandra S. Skarabahatava, Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus

PhD (biology); scientific secretary of the institute of biophysics and cell engineering

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Published
2021-01-15
Keywords: osteoarthritis, gonarthrosis, coxarthrosis, trace elements, calcium, zinc, copper, iron, peripheral blood, synovial fluid
Supporting Agencies The study was conducted within the framework of the research work «Investigate violations of the microelement composition and microRNA aberrant expression in deforming diseases of the joints under conditions of high anthropogenic load» (No 20191142), the State program of scientific research «Natural resources and ecology», subprogram «Radiation and natural systems»
How to Cite
Koktysh, I. V., Bashura, A. M., Koktysh, V. T., Venskaya, E. I., & Skarabahatava, A. S. (2021). Microelement composition investigation in peripheral blood and synovial fluid in osteoarthritis. Journal of the Belarusian State University. Ecology, 4, 52-58. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/3644
Issue
No 4 (2020): Journal of the Belarusian State University. Ecology
Section
Medical Ecology