Hematological integrated indicators in assessing the cellular reactivity of the body in COVID-19 coronavirus infection
Abstract
The article analyzes the disorders in homeostasis diagnosed during the development of acute viral infection SARS-CoV-2 in patients. Hematological changes in patients with coronavirus infection were characterized by the development of disintegration of humoral mechanisms of regulation with the initiation of a systemic inflammatory reaction with an increase in the leukocyte index of intoxication, activation of necrobiotic processes, an increase in the activity of macrophage-microphage nonspecific protection with a predominance of effector links of the immunological process. The development of immunocompromise in patients with a new strain of coronavirus infection is one of the determining factors in the course of the disease.
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2. Chen Yu, Qianyun Liu, Guo Deyin. Emerging coronaviruses: genome structure, replication, and pathogenesis. Journal of Medical Virology. 2020;92 (4):418–423.
3. Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin [published online ahead of print, 2020 February 03]. Nature. 2020. DOI: 10.1038/s41586-020-2012-7.
4. Geng L, Fan Y, Lai Y et.al. Coronavirus infections and immune responses. Journal of Medical Virology. 2020;92:424–432.
5. Hoffmann M, Kleine-Weber H, Krueger N, et al. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells [published online ahead of print, 2020 January 31]. bioRxiv. 2020. DOI: org/10.1101/2020.01.31.929042.
6. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [published online, 2020 February 07]. JAMA. DOI: 10.1001/jama.2020.1585.
7. Pan Luo, Dong Liu*, Juan Li. Pharmacological perspective: glycyrrhizin may be an efficacious therapeutic agent for COVID-19. International Journal of Antimicrobial Agents [published online, 2020 April 29]. DOI: 10.36233/0507-4088-2020-65-1-6-15.
8. Смолякова РМ. Клеточные тесты реактивности и показатели интоксикации в оценке гнойно-воспалительных осложнений у онкологических больных. Медицинская панорама. 2004;5:11–14.
Published
2021-04-09
Keywords:
SARS-CoV-2 coronavirus infection, homeostasis, cellular composition of peripheral blood, integral hematological parameters of the body’s cellular reactivity
How to Cite
Smolyakova, R. M., KozyrevaH. А., & Shpadaruk, K. M. (2021). Hematological integrated indicators in assessing the cellular reactivity of the body in COVID-19 coronavirus infection. Journal of the Belarusian State University. Ecology, 1, 77-84. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/3884
Section
Medical Ecology
