Immunological features in children with hemorrhagic vasculitis

  • Darya B. Nizheharodava International Sakharov Environmental Institute, Belarusian State University https://orcid.org/0000-0003-1633-7487
  • Galina M. Batsian Belarusian State Medical University
  • Mariya Yu. Yurkevich International Sakharov Environmental Institute, Belarusian State University https://orcid.org/0000-0002-5082-5874
  • Marina M. Zafranskaya International Sakharov Environmental Institute, Belarusian State University

Abstract

Currently the incidence of hemorrhagic vasculitis in children is characterized by an increase in all age groups what may be associated with environmental problems, chronic infection as well as food and drugs allergy. To date there are no biomarkers predicting the further development of hemorrhagic exanthema at the onset of the disease and followed its outcome. The quantitative and functional features of cellular and humoral immunity in children with hemorrhagic vasculitis of various origins accompanied by hemorrhagic exanthema at the onset of the disease are presented in this article. The reduction of γδТ-cells number in the peripheral blood correlated with levels of specific antineutrophil cytoplasmic antibodies and IgG EBNA-1 antibodies against a high ability of γδТ-cells to activation were established in children with systemic (immunocomplex) vasculitis. At the contrast, the background of a normal γδT-lymphocytes’ content was associated with the decrease in γδТ-cells activation capacity in children with hemorrhagic vasculitis of infectious-allergic genesis. Thus, quantitative and functional changes in γδТ-lymphocytes can be a potential labor biomarker for early diagnosis of systemic or infectious-allergic hemorrhagic vasculitis in children what may be used for the further disease course prediction.

Author Biographies

Darya B. Nizheharodava, International Sakharov Environmental Institute, Belarusian State University

PhD (biology); docent; associate professor at the department of immunology, faculty of ecological medicine

Galina M. Batsian, Belarusian State Medical University

PhD (medicine), docent; associate professor at the 1st Childhood diseases department

Mariya Yu. Yurkevich, International Sakharov Environmental Institute, Belarusian State University

PhD (biology); associate professor at the department of immunology.

Marina M. Zafranskaya, International Sakharov Environmental Institute, Belarusian State University

doctor of science (medicine), docent; head at the department of immunology, faculty of ecological medicine, ISEI BSU; primary investigator at the department of immunology and biomedicine technology, scientific research labor.

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Published
2021-04-09
Keywords: hemorrhagic vasculitis, immune system, phenotype, lymphoid cells, antibodies
How to Cite
Nizheharodava, D. B., Batsian, G. M., Yurkevich, M. Y., & Zafranskaya, M. M. (2021). Immunological features in children with hemorrhagic vasculitis. Journal of the Belarusian State University. Ecology, 1, 85-95. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/3885