Peculiarities of breast cancer incidence according to Vitebsk Regional Clinical Oncological Dispenser

  • Yuliya Yu. Masalkova Vitebsk State Medical University https://orcid.org/
  • Darya I. Beliaeva Vitebsk State Medical University https://orcid.org/

Abstract

The results of statistical processing of data on the diagnostics of breast cancer in patients of the Vitebsk Regional Clinical Oncological Dispensary for 2019-2020 are presented in this article. Extracts from medical records of 1061 patients (617 - 2019; 444 - 2020) aged 20 to 99 years were analyzed. In particular, methods for diagnosing the disease, the stages of registration of breast cancer were studied, the circumstances of the detection of the disease, the ratio of lesions of different parts of the mammary gland according to ICD-10, the results of the analysis of the occurrence of the disease depending on age, the features of the occurrence of relapses and metastases, the mortality of patients of different age groups, the ratio of patients from urban and rural areas.

In 91.99 % of cases, the histological method was used to diagnose the disease. Echoscopic (0.75 % of cases) and X-ray (0.28 % of cases) diagnostic methods have found the least use. In the majority (45.80 % of cases) the disease was detected at stage II, in 7.71 % of cases breast cancer was registered at stage IV. In more than half of the cases (50.51 %), the disease affected the upper outer quadrant of the breast, which corresponds to the ICD-10 code C50.4 (Malignant neoplasm of the upper outer quadrant of the breast). There was an increase in the risk of breast cancer with increasing age of patients (approximation - 0.9577) with an average age of patients - 62 years. Relapses and metastases were found in 13.57 % of patients with breast cancer, and in 36.81 % of cases - at stage IV of the disease. Among patients, the largest number of relapses and metastases (22 cases each) was found in the age groups 55-59 and 60-64 years. Mortality for 2019-2020 was 7.92 % (84 patients died, among which relapses and metastases were detected in 38 people). Most of all patients (77.57 %) with diagnosed breast cancer live in urban areas, 22.43 % are patients from rural areas.

Author Biographies

Yuliya Yu. Masalkova, Vitebsk State Medical University

PhD (biology); associate professor at the department of environmental and preventive medicine

Darya I. Beliaeva, Vitebsk State Medical University

student of medical faculty

References

1. Parkin DM, Bray F, Ferlay J. Global cancer statistics, 2002. Cancer Journal Clinical. 2005;55:74-108.
2. Okeanov АЕ, et al. Rak v Belarusi: cifry i facty. Analis dannyh kancerregistra Belarusi za 2010-2019 goda [Cancer in Belarus: figures and facts. Analysis of the data of the Belarusian Cancer Registry for 2010-2019]. Minsk: RSPC OMR named after N. N. Aleksandrov; 2020. 298 p. Russian.
3. Globocan 2020 [Internet; cited 2021 April 1]. The Global Cancer Observatory. Available from: https://gco.iarc.fr/today/data/ factsheets/populations/112-belarus-fact-sheets.pdf.
4. Stogharov АН. Ekologicheskaja medicina [Ecological medicine]. Minsk: MSMI; 2000. 151 p. Russian.
5. Cohn BA, Wolff MS, Cirillo PM, Sholtz RI. DDT and breast cancer in young women: new data on the significance of age at exposure. Environmental Health Perspectives. 2007;115(10):1406-1414.
6. Kortenkamp A. Breast cancer, oestrogens and environmental pollutants: a re-evaluation from a mixture perspective. International Journal of Andrology. 2006;29:193-198.
7. Donovan M, Tiwary CM, Axelrod D, Sasco AJ, Jones L, Hajek R, Sauber E, Kuo J, Davis DL. Personal care products that contain estrogens or xenoestrogens may increase breast cancer risk. Medical Hypotheses. 2007;68(4):756-766.
8. Safe S, Papineni S. The role of xenoestrogenic compounds in the development of breast cancer. Trends in Pharmacological Sciences.2006;27(8):447-454.
9. Brody JG, Rudel RA. Environmental pollutants and breast cancer. Environmental Health Perspectives. 2003;111(8):1007-1019.
10. Badmaeva GS, Oloeva ТТ, Perinov AP, Boloshinov AB. Ecology and breast cancer in Buryatia. Sibirskij onkologicheskij ghurnal [Siberian journal of oncology]. 2002;3-4:29. Russian.
11. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer. Analyses of cohorts of twins from Sweden, Denmark and Finland. New England Journal of Medicine. 2000;343:78-85.
12. Shimizu H, Ross RK, Bernstein L, Yatani R, Henderson BE, Mack TM. Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County. British Journal of Cancer. 1991;63(6):963-966.
13. King MC, Marks JH, Mandell JB. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science.2003;302: 643-646.
14. Vallejos CS, Gomez LH, Cruz WR, Pinto JA, Dyer RR, Velarde R, Suazo JF, Neciosup SP, Mauricio L, de la Cruz MA, Vigil CE. Breast Cancer Classification According to Immunohistochemistry Markers: Subtypes and Association With Clinicopathologic Variables in a Peruvian Hospital Database. Clinical Breast Cancer. 2010:10(4):294-300.
Published
2022-05-05
Keywords: breast cancer, ecology, environmental factors, diagnostics, pathogenesis, mortality, treatment
How to Cite
Masalkova, Y. Y., & Beliaeva, D. I. (2022). Peculiarities of breast cancer incidence according to Vitebsk Regional Clinical Oncological Dispenser. Journal of the Belarusian State University. Ecology, 1, 68-74. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/4793