Diadenosine tetraphosphate effect on the functional activity of pregnant women with pre-eclampsia at oxidative stress

  • Andrei V. Bakunovich International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus
  • Leonid M. Lobanok Belarusian State Medical University, 83 Dzjarzhinskaga Avenue, Minsk 220116, Belarus
  • Anatoly I. Zinchenko International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus; Institute of Microbiology of the National Academy of Sciences of Belarus, 2 acad. V. F. Kuprevich, Minsk 220141, Belarus
  • Klavdiya Ya. Bulanova International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

Abstract

Pregnant women with pre-eclampsia have no significant increase in the degree of platelet aggregation in response to the action of hydrogen peroxide, compared with a physiologically occurring pregnancy. In vitro experiments revealed that diadenosine tetraphosphate reduces the degree and rate of platelet aggregation induced by hydrogen peroxide in pregnant women with physiologically occurring pregnancy and pre-eclampsia.

Author Biographies

Andrei V. Bakunovich, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

senior lecturer at the department of ecological chemistry and biochemistry

Leonid M. Lobanok, Belarusian State Medical University, 83 Dzjarzhinskaga Avenue, Minsk 220116, Belarus

corresponding member of the National Academy of Sciences of Belarus, doctor of science (medicine), full professor; professor at the department of normal physiology

Anatoly I. Zinchenko, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus; Institute of Microbiology of the National Academy of Sciences of Belarus, 2 acad. V. F. Kuprevich, Minsk 220141, Belarus

corresponding member of the National Academy of Sciences of Belarus, doctor of science (biology), full professor; head of the laboratory of molecular biotechnology; professor at the department of ecological chemistry and biochemistry

Klavdiya Ya. Bulanova, International Sakharov Environmental Institute of Belarusian State University, 23/1 Daŭhabrodskaja, Minsk 220070, Belarus

PhD (biology), docent; associate professor at the department of ecological chemistry and biochemistry

Published
2019-08-16
Keywords: pre-eclampsia, platelets, aggregation, hydrogen peroxide, diadenosine tetraphosphate
How to Cite
Bakunovich, A. V., Lobanok, L. M., Zinchenko, A. I., & Bulanova, K. Y. (2019). Diadenosine tetraphosphate effect on the functional activity of pregnant women with pre-eclampsia at oxidative stress. Journal of the Belarusian State University. Ecology, 2, 60-67. Retrieved from https://journals.bsu.by/index.php/ecology/article/view/2708
Issue
No 2 (2019): Journal of the Belarusian State University. Ecology
Section
Medical Ecology

Copyright (c) 2019 Journal of the Belarusian State University. Ecology

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