Control of conductance through electrical synapses by non-specific extrasynaptic agents

  • Alexander V. Sidorov Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

Abstract

The article deals with the structure functional configuration of gap junctions and control of their permeability. Based on the reactions of identified electrical synapse between V. D. 1 and R. Pa. D. 2 neurons within central nervous system of mollusc Lymnaea stagnalis the responses of mentioned above connections to temperature changes, acid-base balance (pH) shifts and increase of reactive oxygen species (hydrogen peroxide) level were analysed. Time-course of effects observed (minutes), give the evidence of fast dynamic modulation of electrotonical coupling. The fluctuations in it conductance seems to be due to the changes in conductivity of exist gap junctions channels (innexons), but not to the alterations in their number in the junction area. It is assumed that the action of these agents realize by reversible conformational transition of gap junction structural proteins (innexins).

Author Biography

Alexander V. Sidorov, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

doctor of science (biology), docent; professor at the department of human and animal physiology, faculty of biology

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Published
2018-05-03
Keywords: идентифицированные нейроны, temperature, acid-base balance, reactive oxygen species, identified neurons
Supporting Agencies This work supported by Belarusian Republican Foundation for Fundamental Research (grants No. B05M-055, B08R-075) and State Programs for Scientific Research «Convergence» (task 3.3.03.4).
How to Cite
Sidorov, A. V. (2018). Control of conductance through electrical synapses by non-specific extrasynaptic agents. Experimental Biology and Biotechnology, 1, 3-12. Retrieved from https://journals.bsu.by/index.php/biology/article/view/2481
Issue
No 1 (2018): Journal of the Belarusian State University. Biology
Section
Physiology and Сell Biology

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