Immunobiological characteristics of microglial cells and in vitro models for their obtaining

  • Veranika E. Mantsivoda Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus
  • Natalia G. Antonevich Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus
  • Andrei Y. Hancharou Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus
DOI: https://doi.org/10.33581/2957-5060-2022-3-4-13

Abstract

Microglial cells are one of the main cellular elements of the central nervous system. In recent years, more and more data has appeared about the role of microglial cells in the pathogenesis of various mental and neurodegenerative diseases. However, the study of human brain microglia is limited for technical and ethical reasons, so the development of a new in vitro cell model of human microglia is a perspective trend in biology and medicine. The aim of this review is to describe the functional and immunological properties of microglia and to analyse in vitro models that currently used for study the properties of cells in normal and pathological conditions.

Author Biographies

Veranika E. Mantsivoda, Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus

junior researcher at the laboratory of immunology and cell biophysics

Natalia G. Antonevich, Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus

PhD (biology); head of the laboratory of immunology and cell biophysics

Andrei Y. Hancharou, Institute of Biophysics and Cell Engineering, National Academy of Sciences of Belarus, 27 Akademičnaja Street, Minsk 220072, Belarus

PhD (medicine), docent; director

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Published
2022-10-28
Keywords: microglia, microglia-like cells, in vitro models, cell biology
How to Cite
Mantsivoda, V. E., Antonevich, N. G., & Hancharou, A. Y. (2022). Immunobiological characteristics of microglial cells and in vitro models for their obtaining. Experimental Biology and Biotechnology, 3, 4-13. https://doi.org/10.33581/2957-5060-2022-3-4-13
Issue
No 3 (2022): Experimental Biology and Biotechnology
Section
Reviews

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