Determination of rimantadine in dosage form «Grippomix» using the ion-selective electrode

  • Kseniya V. Andronchyk Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk
  • Vladimir V. Egorov Research Institute for Physical Chemical problems of the Belarusian State University, Belarusian State University

Abstract

The possibility of direct potentiometric rimantadine determination in dosage form «Grippomix» using the ion-selective electrode (ISE) with the membrane based on tetrakis(4-chlorophenyl)borate (TCPB) as the ion-exchanger was investigated. It was shown that from all components of the dosage form only cetirizine can significantly influence on the electrode functioning. It was found that the replacement of o-phenyloctylether as the plasticizer by the tris(2-ethylhexyl) phosphate (TEHP) in the electrode membrane can reduce the influence of cetirizine almost in 30 times. The ISE membrane with 0.5 % of TCPB, 66.5 % of TEHP and 33.0 % of polyvinylchloride as the polymer matrix demonstrates the linear response to rimantadine in the concentration range 1 ⋅ 10–5–1 ⋅ 10–1 mol / l with the slope of electrode function close to the nernstian one (58.6 mV/decade at 20 °C), lower detection limit 6 ⋅ 10– 6 mol / l and retains operability for 6 months. Standard deviation of electrode potential in the 1 ⋅ 10–3 mol / l rimantadine solution is 0.33 mV. The pH variation from 2 to 9 do not affect at the ISEs response to rimantadine. On the other hand, the response to cetirizine cation depends on pH and at рН ≥ 3 it drastically reduces because of cetirizine transformation to electrode inactive zwitterion form. The influence of cetirizine on the rimantadine-selective electrode response is fully suppressed if analysis is carried out in phosphate buffer medium (pH 6.86). Standard solution method (one-point calibration) and limiting solutions method (two-point calibration) are proposed for direct potentiometric rimantadine determination. Both techniques are characterized by high reproducibility (Sr ≤ 0.6 %), precision estimated by the criterion «introduced/labeled – found» was no worse than 0.8 %.

Author Biographies

Kseniya V. Andronchyk, Research Institute for Physical Chemical problems of the Belarusian State University, Leningradskaya street, 14, 220006, Minsk, Belarusian State University, Nezavisimosti avenue, 4, 220030, Minsk

 junior researcher at the Research Institute for Physical Chemical problems of the Belarusian State University, senior lecturer at the department of analytical chemistry, faculty of chemistry of Belarusian State University

Vladimir V. Egorov, Research Institute for Physical Chemical problems of the Belarusian State University, Belarusian State University

doctor of science (chemistry), full professor; head of the laboratory at the Research Institute for Physical Chemical problems of the Belarusian State University, professor at the department of analytical chemistry, faculty of chemistry of the Belarusian State University

References

  1. Mashkovskii M. D. Lekarstvennye sredstva (Pharmaceuticals). Mosc., 2005.
  2. Belarus Pharmacopeia. Minsk, 2005.
  3. Higashi Y., Uemori I., Fujii Y. Simultaneous determination of amantadine and rimantadine by HPLC in rat plasma with pre-column derivatization and fluorescence detection for pharmacokinetic studies. Biomed. Chromatogr. 2005. Vol. 19, No. 9. P. 655– 662.
  4. Han J., Fu H. Determination of rimantadine hydrochloride in compound rimantadine hydrochloride capsules by capillary gas chromatography. Chin. J. Chromatogr. 2005. Vol. 23, No. 6. P. 683.
  5. Pazourek J., Revilla A. L., Gajdsova D., et al. Validation of a capillary zone electrophoresis method for determination of rimantadine hydrochloride in Rimantadine100 tablets and the method application to dissolution test monitoring. Drug Dev. Industrial Pharm. 2004. Vol. 30, No. 2. P. 125–134.
  6. Revilla A. L., Hamacek J., Lubal P., et al. Determination of rimantadine in pharmaceutical preparations by capillary zone electrophoresis with indirect detectiom or after derivatization. Chromatographia. 1998. Vol. 47, No. 7. P. 433– 439.
  7. Muszalska I., Sobczak A., Kiaszewicz I., et al. 1,2-naphthoquinone-4-sulfonic acid sodium salt as a reagent for spectrophotometric determination of rimantadine and memantine. J. Anal. Chem. 2015. Vol. 70, No. 3. P. 320 –327.
  8. Sobczak A., Muszalska I., Rohowska P., et al. Determination of adamantine derivatives in pharmaceutical formulations by using spectrophotometric UV-Vis method. Drug Dev. Industrial Pharm. 2013. Vol. 39, No. 5. P. 657– 661.
  9. Titova A. V., Arzamastsev A. P., Gretskii S. V. Analysis of rimantadine hydrochloride be near-ir spectroscopy. Pharm. Chem. J. 2009. Vol. 43. P. 534.
  10. Gupta V. K., Nayak A., Agarwal S., et al. Recent advances on potentiometric membrane sensors for pharmaceutical analysis. Comb. Chem. & High Throughput Screen. 2011. Vol. 14. P. 284 –302.
  11. Kharitonov V. S. Ion-selective electrodes in medical drug determination. Russ. Chem. Rewiews. 2007. Vol. 76, No. 4. P. 361–395.
  12. Cosofret V. V., Buck R. P. Recent advances in pharmaceutical analysis with potentiometric membrane sensors. Crit. Reviews Anal. Chem. 1993. Vol. 24, No. 1. P. 1–58.
  13. Stefan R.-J., Baiulescu G. E., Aboul-Enien H. Y. Ion-selective membrane electrodes in pharmaceutical analysis. Crit. Reviews Anal. Chem. 1997. Vol. 27, No. 4. P. 307–321.
  14. Cosofret V. V., Buck R. P. Pharmaceutical applications of membrane sensors. Boca Raton, 1992.
  15. Stefan R.-J., van Staden J. F., Aboul-Enien H. Y. Electrochemical sensors in bioanalysis. N. Y., 2001.
  16. Bolotin A. A., Egorov V. V., Boyarina T. P. Determination of rimantadine in tablets using the rimantadine-selective electrides. Vestnik BGU. Ser. 2, Khim. Biol. Geogr. 2007. No. 2. P. 23–30.
  17. Egorov V. V., Nazarov V. A., Svirshhevskij S. F. Calculation of ligand numbers and conditioanal stability constants of heptyl p-trifluoroacetylbensoic acid ether complexes with various anions from potentiometric data. Vestnik BGU. Ser. 2, Khim. Biol. Geogr. 2007. No. 2. P. 13–22.
  18. Egorov V. V., Bolotin A. A. Ion-selective electrodes for determination of organic ammonium ions: Ways for selectivity control. Talanta. 2006. Vol. 70. P. 1107–1116.
  19. Egorov V. V., Astapovich R. I., Bolotin A. A., et al. The influence of the plasticizer nature on the selectrivity of ion-selective electrodes to physiologically active amine cations: Regularities and abnormalities. J. Anal. Chem. 2010. Vol. 65, No. 4. P. 404 – 413.
Published
2017-11-29
Keywords: ion-selective electrode, direct potentiometry, rimantadine, pharmaceutical analysis
How to Cite
Andronchyk, K. V., & Egorov, V. V. (2017). Determination of rimantadine in dosage form «Grippomix» using the ion-selective electrode. Journal of the Belarusian State University. Chemistry, 1, 25-30. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/1154
Issue
No 1 (2017): Journal of the Belarusian State University. Chemistry
Section
Original Articles

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