Anion-exchange extraction of mefenamic acid

  • Alyaksandr L. Gulevich Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Evgenii M. Rakhman’ko Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus
  • Vladimir V. Egorov Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Marina S. Smirnova Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

Abstract

Anion-exchange extraction of mefenate anions with toluene solutions of trinonyloctadecylammonium picrate was studied. It has been established that the introduction of solvents with acid properties – chloroform and n-octylalcohol – into the organic phase leads to a sharp increase in the concentration exchange constants. The greatest effect was observed when trifluoroacetyl solvating additives were introduced into the organic phase. The corresponding solvation constants and average solvate numbers are calculated. A simple and selective extraction-photometric method for the quantitative determination of mefenamic acid in the drug «Mefenamic acid-Darnitsa» has been developed. 

Author Biographies

Alyaksandr L. Gulevich, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

doctor of science (chemistry); professor at the department of analytical chemistry, faculty of chemistry

Evgenii M. Rakhman’ko, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

doctor of science (chemistry), full professor; head of the department of analytical chemistry, faculty of chemistry

Vladimir V. Egorov, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

doctor of science (chemistry), full professor; professor at the department of analytical chemistry, faculty of chemistry, Belarusian State University, principal scientific researcher, Research Institute for Physical Chemical Problems, Belarusian State University

Marina S. Smirnova, Belarusian State University, Niezaliežnasci Avenue, 4, 220030, Minsk, Belarus

postgraduate student at the department of analytical chemistry, faculty of chemistry

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Published
2019-01-19
Keywords: anion-exchange extraction, high-molecular quaternary ammonium salts, mefenamic acid, trifluoroacetyl solvating agent
How to Cite
Gulevich, A. L., Rakhman’ko, E. M., Egorov, V. V., & Smirnova, M. S. (2019). Anion-exchange extraction of mefenamic acid. Journal of the Belarusian State University. Chemistry, 2, 10-17. Retrieved from https://journals.bsu.by/index.php/chemistry/article/view/1236
Issue
No 2 (2018): Journal of the Belarusian State University. Chemistry
Section
Original Articles

Copyright (c) 2018 Journal of the Belarusian State University. Chemistry

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