Free radical destruction of hydroxyl-containing amino acids

  • Anastasia A. Sladkova Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Irina P. Edimecheva Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Anna A. Sosnovskaya Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
  • Oleg I. Shadyro Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus
DOI: https://doi.org/10.33581/2520-257X-2019-1-3-13

Abstract

А new way of the free radical ROS- and HOCl-induced destruction of serine, threonine, and their peptide derivatives due to the nitrogen-centered radicals formation and their subsequent decomposition with the side chain elimination has been established. It has been shown that substances with reducing properties are inhibitors of this process, while oxygen does not affect the probability of its occurrence. The data obtained are relevant for the development of novel approaches to the search for effective free radical processes regulators.

Author Biographies

Anastasia A. Sladkova, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry); associate professor at the department of radiation chemistry and chemical-pharmaceutical technology, faculty of chemistry, Belarusian State University, and senior researcher at the laboratory of chemistry of free radical processes, Research Institute for Physical Chemical Problems, Belarusian State University

Irina P. Edimecheva, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry); leading researcher at the laboratory of chemistry of free radical processes

Anna A. Sosnovskaya, Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

PhD (chemistry); leading researcher at the laboratory of chemistry of free radical processes

Oleg I. Shadyro, Belarusian State University, 4 Niezaliežnasci Avenue, Minsk 220030, Belarus; Research Institute for Physical Chemical Problems, Belarusian State University, 14 Lieninhradskaja Street, Minsk 220006, Belarus

doctor of science (chemistry), full professor; head of the department of radiation chemistry and chemi- cal-pharmaceutical technology, faculty of chemistry, Belarusian State University, and head of the laboratory of chemistry of free radical processes, Research Institute for Physical Chemical Problems, Belarusian State University

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Published
2019-02-15
Keywords: serine, threonine, free radical reactions, carbon skeleton destruction, biochemical reactions
How to Cite
Sladkova, A. A., Edimecheva, I. P., Sosnovskaya, A. A., & Shadyro, O. I. (2019). Free radical destruction of hydroxyl-containing amino acids. Journal of the Belarusian State University. Chemistry, 1, 3-13. https://doi.org/10.33581/2520-257X-2019-1-3-13
Issue
No 1 (2019): Journal of the Belarusian State University. Chemistry
Section
Original Articles

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